Biopotential of secondary metabolites isolated from marine sponge Dendrilla nigra
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2011, Vol 1, Issue 4
Abstract
Objective: To evaluate the biopotential activity of secondary metabolites from marine sponge Dendrilla nigra (D. nigra) collected from the Gulf of Mannar. Objective: Soxhlet extraction method was used to extract the secondary metabolites and various assays were carried out. Results: D. nigra showed potent antibacterial, antioxidant, anti-inflammatory and anticancer activities and it was also subjected for brine shrimp lethality and cytotoxicity assays. The secondary metabolites were characterized by gas chromatography-mass spectrometry (GC-MS) analysis. Conclusions: Based on the present study, it can be inferred that the bioassay guided fractionation and purification of D. nigra may come up with potent bioactive drug.
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