Biosensor Platforms for Cancer Derived Exosomes Detection
Journal Title: Yeni Yuzyil Journal of Medical Sciences - Year 2021, Vol 2, Issue 3
Abstract
Early diagnosis is one of the biggest challenges in the fight against cancer. Traditional cancer diagnosis methods have some disadvantages such as requiring expertise, involving invasive procedures, radiation exposure, high cost and loss of time. For this reason, current research has focused on the development of faster, reliable and cost-effective diagnostic methods. The use of biomarkers present in body fluids has been promising in this regard. Exosomes secreted by cells into body fluids and responsible for intercellular communication are biological nanoparticles produced by natural pathways. Studies have shown that the change in microenvironmental conditions during tumor development changes exosome secretion. Due to their high cellular activities, tumor cells produce a much higher rate of exosome than healthy cells. Therefore, it is known that the number of exosomes in body fluids is significantly enriched compared to other cells and can act as a diagnostic biomarker alone. Cancer-derived exosomes are very interesting for early detection of cancer and evaluation of therapeutic response. Biosensor is an analytical device used to detect an analyte that combines a biological component with a physicochemical detector. Nowadaysthere is an increasing interest in developing cancer biosensors with superior analytical performance and real-time measurement. The development and dissemination of biosensor applications for exosome detection will be very advantageous for individuals in regions where there is no access to diagnostic devices and resources. Considering the disadvantages of traditional methods, we can say that biosensor studies are much more advantageous because they are cheaper, provide multi-analyte support, provide high sensitivity, and obtain fast and reliable results. In this study, recent developments in biosensor systems for the detection of exosomes secreted from different cancer cells are summarized. In addition, the use of cancer-secreted exosomes for point of care testing (POC) and the challenges in this area are presented and discussed.
Authors and Affiliations
Kübra KELLECİ, Sevil ÖZER
Keywords
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- EP ID EP698169
- DOI https://doi.org/10.46629/JMS.2021.45
- Views 91
- Downloads 0
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