Black Tea (Camellia sinensis) Extract Induced Changes on Placenta can Alter Fetal and Neonatal Bone Health in Experimental Animal Model
Journal Title: Advances in Clinical Toxicology - Year 2020, Vol 5, Issue 4
Abstract
Tea (Camellia sinensis) being the most consumed beverage worldwide. The safety evaluation of tea needs to be monitored during pregnancy, prenatal and postnatal developmental period beside its beneficial roles toward health and disease. Retardation of growth of fetus and neonates are common in preeclampsia. Present study was to evaluate the role of Black Tea extract (BTE) on placental and apoptotic markers in pregnant Wister albino rats and to correlate it the growth of fetus and pups. Among three experimental groups, Group 1 was pregnant female rats treated with saline, were the control group. Group 2 and Group 3 were pregnant female rats treated with 50 mg and 100 mg BTE/kg/day, p.o. respectively throughout prenatal and postnatal periods. Expressions of BMP-7, MMP-2 and VEGFR2 in placenta were examined by flow cytometry; Bax, Bcl-2 and caspase-3 expressions in uteri and placenta were observed by IHC. Bone health of fetus and pup were checked by histology, bone-cartilage double staining and estimation of bone mineral density by ICP-MS. Experimental data were subjected to the ANOVA; expressed as mean ± standard deviation with significance (P < 0.05) between the controls and the treated groups (n = 6). BTE increased the level of MMP-2, Bax and caspase-3; decreased the level of BMP-7 in placenta. In fetus and pups, BTE significantly decreased the concentration of Ca2+, P, Mg2+ and Zn2+ in bone and decreased the rate of ossification were observed. This study confirmed BTE induced preeclampsia retarded the fetal and neonatal bone health in experimental animal model.
Authors and Affiliations
Dey A, Gomes A, Chakraborty K and Dasgupta SC*
Keywords
Related Articles
- EP ID EP751768
- DOI 10.23880/act-16000201
- Views 48
- Downloads 0
The Menace of Lead Poisoning in Pakistan
Environmental pollution has been increased many times due to increase in population, industrialization and urbanization; in some places, it becomes toxic to living organisms. Among the pollutants, heavy metals pose th...
The Role of VGLL4 in Development and Progression of Tumors
The Hippo pathway plays an important role in controlling the size of organs, as well as cell proliferation, apoptosis and tumor formation. VGLL is a recently discovered family of proteins that can interact with TEAD, a t...
On Autism: One Case
In this paper, we develop an equation for Autism. We make use of detailed knowledge of his diet and behaviour. The basic problem is that he has too much serotonin which enlivens the senses. It’s the opposite of depress...
Natural Co-Occurrence of Aflatoxins, Cyclopiazonic Acid, and their Production by Aspergillus Flavus Isolates from Corn Grown in Egypt
Mycotoxins are metabolites of fungi that can adversely affect animal and human health. Mycotoxins can be produced in corn during storage or processing, but are most frequently associated with fungal infection that occur...
Fennel Essential Oil Prevents Cytotoxicity and Genotoxicity Induced by Triflumuron in Two Human Cell Lines
Background: Among insecticides belonging to the insect growth regulators class, we are interested in this present work in the study of Triflumuron (TFM) which is widely used in the protection of crops, human and animal h...