Black Women's Predisposition to Preterm Birth; Could We Be Near The Answer?
Journal Title: International Journal of TROPICAL DISEASE & Health - Year 2014, Vol 4, Issue 2
Abstract
Background: Pre-term Premature Rupture of Membranes (PPROM) is attributable to several causes including asymptomatic bacterial vaginosis among Caucasians and is commoner among black pregnant women. While malaria and high Body Mass Index (BMI) have been reported among Nigerians, the influence of metalloproteinases on PPROM has never been studied in Nigeria. Methods: A qualitative estimation of active matrixmetalloproteinase-8 (a-MMP-8) to assess the effect of chronic periodontitis on time to conception led to an accidental discovery of widespread elevation of a-MMP-8 among pregnant participants. Values of a-MMP-8 were compared across demographics of participants as well as educational status, BMI and other parameters. Results : One hundred and seventeen of 134 participants (117, 87.3%) had elevated a-MMP-8 based on a novel qualitative assessment using salivary diagnostics. Levels were increased across independent of age, Estimated Gestational Age(EGA), BMI, educational level and trimester. Conclusion: This population of black pregnant women exhibited higher a-MMP-8 levels than reported among pregnant Caucasians independent of demographics, educational level and trimester of pregnancy. Reasons for the association need to be further investigated.
Authors and Affiliations
S. O. Nwhator, K. A. Umeizudike, P. O. Ayanbadejo, G. A. Agbelusi, M. Arowojolu, T. Sorsa, O. I. Opeodu, J. A. Olamijulo, G. O. Akaba, B. A. Ekele
Keywords
Related Articles
- EP ID EP343559
- DOI 10.9734/IJTDH/2014/6669
- Views 55
- Downloads 0
Nigeria National Health Insurance Scheme: A Highly Subsidized Health Care Program for a Privileged Few
The National Health Insurance Scheme (NHIS) of Nigeria was established over a decade ago with the aim of achieving universal health coverage within ten years of inception. Currently the population coverage is less than 1...
Prevalence of ABO Blood Groups and Its Relationship with Malaria Parasitemia among Students of Federal University of Technology, Akure, Ondo State
There are different reports on the increasing evidence about the relationship between Plasmodium falciparum malaria and ABO blood group, but the range is yet to be understood. The aim of the study was to investigate the...
Dietary Pattern and Antioxidants Levels in Patients with Simple Goiter and Thyroid Cancer
Background /Aims: Oxidative stress has been implicated in the pathogenesis of thyroid cancer and simple goiter among other diseases however; there has not been a direct comparison of the severity of the stress factor in...
A Cross-sectional Study of Adherence to Lifestyle Modifications among Ambulatory Type 2 Diabetic Nigerians in a Resource-poor Setting of a Primary Care Clinic in Eastern Nigeria
Background: Despite the evidence that lifestyle modifications (LSMs) play important role in glycaemic control, adherence to healthy lifestyles has been variable in Nigeria and this has great impact on the success or fail...
Microhabitat Assessment of the Breeding Sites of Simulium damnosum Theobald Complex in Oji River Basin, Enugu State Nigeria
Aims: Blackflies of the Simulium damnosum complex are the principal vectors of Onchocerca volvulus, the causative agent of Onchocerciasis (river blindness) in Nigeria and other West African countries. They therefore cons...