Blast Comparision of Denv Serotypes
Journal Title: IOSR Journal of Nursing and health Science - Year 2019, Vol 7, Issue 1
Abstract
Dengue virus (DENV) has emerged as major health concern, as DENV infection has been shown to be associated with severe disease symptoms. As the largest protein component within the DENV replication complex, NS5 plays key roles in the life cycle and survival of the virus through its N‐terminal methyltransferase (MTase) and C‐terminal RNA‐dependent RNA polymerase (RdRp) domains. Here, we present the blast result of DENV NS5 RdRp. We have identified the conserved features of DENV NS5 RdRp structures that could lead to development of current antiviral inhibitors being used against dengue virus, including flaviviruses.Our structural analysis should inform and accelerate the structure‐based design of antiviral compounds against DENV.This leads to the identification of a potential drug-binding site of DENV NS5, which might facilitate the development of novel antivirals for DENV.
Authors and Affiliations
Kavita Niranjan, Suhasini Bhatnagar
Keywords
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- EP ID EP435167
- DOI 10.9790/1959-0701036972.
- Views 132
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