Bleomycin induced Flagellate Erythema: A Rare and Unique Drug Rash
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2017, Vol 19, Issue 2
Abstract
Bleomycin has been used most commonly in the treatment of Hodgkin’s lymphoma, certain germ cell tumors and for the sclerosis of recurrent pleural effusions. Bleomycin toxicity predominantly affects the skin and lungs. Skin toxicity includes Raynaud’s phenomenon, hyperkeratosis, nail-bed changes and palmoplantar desquamation. Flagellate erythema is an unusual rash occurring specifically during bleomycin use. In the present study, we report a case of bleomycin-induced flagellate erythema in a patient with Hodgkin’s lymphoma (HL). A 45-year-old male was diagnosed with stage IV Hodgkin’s lymphoma and treated with adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy. After 3 months from the initiation of treatment, the patient subsequently developed a generalized pruritus and erythematous linear rash that was most prominent on the trunk, and upper and lower extremities. The patient was commenced on a short course of low-dose oral prednisolone, 20 mg daily, and antihistaminics. Consequently, bleomycin was withheld from the patient’s treatment regimen. The present study describes the case, along with a review of the associated literature.
Authors and Affiliations
Rakesh Patil, Harsha Panchal, Sonia Parikh, Preetam Jain, Ekta Vala, Salil Patkar, Alok Ranjan
Keywords
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