Blood Group and Human Leucocyte Antigen Sub-Type as Determinants to Keloid Formation and Recurrence in Keloid Patients: A Prospective Longitudinal Cohort Study
Journal Title: Journal of Dermatology Research - Year 2021, Vol 2, Issue 3
Abstract
The role of genetic factors in keloid formation is affirmed by the fact that keloids have been shown to occur among members of the same family. We undertook this study to determine whether there is any association between patients’ blood group and HLA sub-types to keloids and keloid recurrence. This was a prospective longitudinal study of patients with keloids and a control of patients managed for other surgical conditions with no keloids. Blood was taken from each patient and analysed for blood group and HLA sub-types using the sequence specific primer geno-typing. Data captured were summarized and analysed using students T-test and Bonferroni correction. Probability values significance was at 0.05. A total of 90 patients with keloids and 59 in a control group were followed up in the study. The male to female ratio of the patients was 1:2. The most common blood group for both groups was blood group O at 51.3% and 49.2%, followed by blood group A and B respectively. Patients with keloids had significantly higher positive alleles of HLADQA1*01 and HLADQB1*06. There was also an association between blood group A and keloid recurrence. In conclusion, this study demonstrates that there is significant difference in some HLA subtypes and blood groups among patients who form keloids and non-keloid forming patients, an indication of the possible role that patients’ genetics and immunity could play in keloid pathogenesis and severity.
Authors and Affiliations
Nangole FW*, Ogeng’o J, Agak G, Ouyang K, Omu A
Keywords
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- EP ID EP699070
- DOI http://dx.doi.org/10.46889/JDR.2021.2302
- Views 47
- Downloads 0
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