Blood group serology and gene detection in patients with B(A) subgroup in Jiaozhou, Qingdao
Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 3
Abstract
Objective To investigate and analyze the serological and molecular biological characteristics of B(A) subgroup in a tertiary hospital in Jiaozhou, Qingdao. Methods From November 2019 to February 2023, the samples of 12 patients were suspected to be AB subgroup by microcolumn glass bead method and saline test tube method. The exons 6 and 7 of ABO gene were further amplified, sequenced and analyzed to determine the ABO allele type. Results A total of 9 cases of B(A) subgroup were detected in 26 065 patients in Jiaozhou, with a detection rate of 0.345 ‰ ( 9/26 065 ). Among the 9 cases of B(A) subgroup, 8 cases of serological reaction showed AweakB, and the gene detection was heterozygous for BA.04 gene and O gene.One case of serological reaction showed ABweak, and the gene detection was heterozygous for BA.04 gene and A gene. Conclusion Blood group serological combined with gene detection can accurately identify ABO blood group. B(A) subgroup alleles can exist in individuals with serological reaction of ABweak.
Authors and Affiliations
Hongwei QIN, Xiaoxia WANG, Ruilan YIN, Shuchao ZHANG
Keywords
Related Articles
- EP ID EP738784
- DOI 10.13303/j.cjbt.issn.1004549x.2024.03.011
- Views 4
- Downloads 0
Incidence of adverse transfusion reactions in Chinese children: a meta-analysis
Objective To systematically evaluate the incidence of adverse transfusion reactions in Chinese children, so as to provide scientific basis for prevention and early intervention. Methods Literature databases such as PubMe...
Diagnosis and treatment recommendations and case study of severe thrombocytopenia caused by tirofiban
Objective To investigate the clinical manifestations, diagnosis, differential diagnosis and management strategies of thrombocytopenia caused by tirofiban. Methods The basic clinical data, platelet count changes and treat...
Influencing factors of the repeat reactive (RR) rates of minipools implicated in minipool(MP) nucleic acid testing(NAT) in Xiamen
Objective To analyze the influencing factors of the repeat reactive (RR) rates of minipools implicated in minipool (MP) nucleic acid testing(NAT) in Xiamen Blood Center, in order to provide reference for NAT. Methods Sam...
Prognostic analysis of perioperative zero red blood cell transfusion in patients with acute Stanford type A
Objective To investigate the correlation between perioperative zero red blood cell(RBC) transfusion and the prognosis of patients with acute Stanford type A aortic dissection. Methods A retrospective analysis was made on...
Efficacy of apheresis platelet transfusion in 310 patients with haematological diseases
Objective To observe the effect of platelet transfusion in inpatients with haematological diseases, analyze the possible causes of platelet transfusion refractoriness (PTR), in order to further improve the efficacy of pl...