Blood Pressure and Cardiac Responses to Isotonic Exercise and Its Modification by Beta Adrenoreceptor Blockade in Human Subjects
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 4
Abstract
Introduction: The role of physical activity in cardio vascular health has received increasing attention in recent years. Exercise has dramatically occupied an unique projection as a recreational activity for the past two decades. Paffernbarger have shown that vigorous exercise is associated with lower incidence of hypertension. The terms aerobic, isotonic and dynamic are used interchangeably to refer to activity that is predominantly fueled by oxidative phospharylation (aerobic), is performed against a constant load that is isotonic and involves the rhythmic contraction of flexor and extensor muscle groups (dynamic). Use of isotonic exercise as non pharmacological therapeutic agent in rehabilitative medicine has become increasingly prevalent and progressively ever gaining prominence. The risk of sudden cardiac death is more common during the exercise than at rest, greater in sedentary subjects, in elderly and in the initial period of programme. In such case, Beta blocking drugs introduced into clinical practice during the past 2 decades. Drugs which block cardiac adrenergic transmission or cardiac beta adrenoreceptors are most effective in attenuating the pressor and tachycardiac response to dynamic exercise. Materials and Methods: Male volunteers of 20-30 years were only chosen for this study. They are moderate built with a mean weight of 58 kgs. Blood pressure, heart rate, and the resting respiratory rate also has been recorded. The subject who is sitting upright is instructed to pedal fast the bicycle. The blood pressure, Heart rate, Respiratory rate are continuously recorded at the end of the one minute interval during the exercise and at the end of 5 minutes on cessation of pedaling. After ensuring complete recovery from stress, in the first propranolol group 80mg of the drug was administered. After 2 hours of administration, all the 4 parameters are recorded and the subject is again subjected to dynamic exercise as above and the same recording done. After ensuring complete recovery from stress, in the second Atenolol group 50mg of the drug was administered. After 2 hours of administration, all the 4 parameters are recorded and the subject is again subjected to dynamic exercise as above and the same recording done. Results: Before the administration of drugs to the individuals the resting parameters are recorded. In case of propronolol, the fall in systolic blood pressure at rest is 12.36%, Diaslostic blood pressure at rest is 14.031%. After administration of Atenolol, the fall in systolic pressure at rest is 10.69% and fall in diastolic pressure at rest is 11.60%. After 1mt isotonic exercise the % of all is 17.14%, in case of Propronolol 13.13 and in case of Atenolol 11.60. The percentage of fall in pulse rate after propronolol is 16.49 at rest and 16.59% after 1mt exercise. In case of Atenolol the pulse rate at rest is 15.08% and after 1mt exercise 12.73%. In relation to propronolol the values are maintained but the effect of Atenolol shows the percentage of all is less which is observed. The percentage of fall in respiratory rate is less in case of propronolol than Atenolol. In case of propronolol the fall at rest is 9.77% and after 1mt exercise 6.67%. In case of Atenolol the fall at rest is 9.1 and after 1mt exercise it will be 13.81.
Authors and Affiliations
Dr V. Malleswaramma
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