Blood serum amino acids profile in patients with Multiple Sclerosis
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2013, Vol 26, Issue 1
Abstract
Multiple sclerosis is the most common demyelinating disease of the central nervous system, affecting mostly young people. There were many risk factors for MS identified, however a direct cause of the disease is still unknown. Pathological changes in the SM lead to the myelin sheath damage around axons, what prevents proper transmission of nerve impulses in the central nervous system. The aim of this study was analyzing and comparing the amino acids profile in the blood serum of MS patients to control group of healthy individuals and evaluating the relationship between them. Significant (p<0.05) differences in the level of glutamate, aspartate and taurine in the blood serum of MS patients were revealed. A positive glutamate and aspartate level correlation in the serum has been demonstrated. Gender is significant only in the case of glutamate level in blood serum. The studies highlight the important role of neurotransmitters in MS and are the initial step in proteomic research.
Authors and Affiliations
Beata Jakubowska-Solarska, Magdalena Nieśpiałowska
Keywords
Related Articles
- EP ID EP94946
- DOI -
- Views 84
- Downloads 0
The origin of the inferior epigastric artery in relation to the inguinal ligament in various periods of human life
The aim of the study was to evaluate the origin of the inferior epigastric artery, in relation to the inguinal ligament, in various stages of human life. The study was conducted on randomly selected 220 non-fixed cadaver...
Effect of mobile phase buffer pH on separation selectivity of some isoquinoline alkaloids in reversed-phase systems of Pressuriz
Separation of some isoquinoline alkaloids (narcotine, chelidonine, dihydrocodeine, cinchonine, berberine, cinchonidine, papaverine, apomorphine) has been investigated with pressurized planar electrochromatography (PPEC)...
Viral safety of blood and its components in modern blood donation – a review
Today, we can observe that blood transfusion is carried out with greater care, which helps to prevent a number of infections in patients. Thus, emphasis is put on non-specific prophylaxis together with regular vaccinatio...
Characteristics of oral probiotics – a review
Probiotics are a group of microorganisms able to have a positive influence on a host organism when applied in adequate amounts. They are grouped either as: bacteria (mainly Lactobacillus spp and Bifidobacterium) or fungi...
Psychological aspects of temporomandibular disorders – literature review
Marcin Berger1, Justyna Oleszek-Listopad2, Milena Marczak3, Jolanta Szymańska4* Temporomandibular disorders (TMD) constitute a group of clinical problems involving the masticatory muscles, the temporomandibular joint...