BLOOD VISCOSITY AS A DETERMINING FACTOR OF ISCHEMIC STROKE OUTCOMES EVALUATED WITH NIHSS AND MRS ON DAY 7 AND 30 POST-THROMBOLYSIS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2019, Vol 11, Issue 9
Abstract
Objective: This study aimed to analyze blood viscosity as a determining factor of ischemic stroke outcomes evaluated with National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) on day 7 and 30 post-thrombolysis. Methods: This study was a 4-months cohort study taking place in Cipto Mangunkusumo General Hospital from January to April 2017. Subjects were collected at the Emergency Department or Neurology Outpatient Department. Eligible patients gave informed consent. Patients underwent numerous examinations, including blood viscosity test using digital microcapillary (DM) instrument. Outcomes of patients were identified on day 7 and day 30 post-thrombolysis using NIHSS and mRS, respectively. Results: Most acute ischemic stroke patients (88.6%) had blood hyperviscosity. 9.1% patients had poorer neurologic deficit on day 7 evaluated with NIHSS and 18.2% patients had poor outcome on day 30 evaluated with mRS. All patients with normal blood viscosity did not have a poorer neurologic deficit on day-7-evaluation. Conclusion: Blood viscosity determines the outcomes of acute ischemic stroke patients on day 7 and day 30 post-thrombolysis.
Authors and Affiliations
Al Rasyid, Salim Harris, Mohammad Kurniawan, Taufik Mesiano, Rakhmad Hidayat, Gogor Meisadona
Keywords
Related Articles
- EP ID EP624901
- DOI 10.22159/ijpps.2019v11i9.34820
- Views 69
- Downloads 0
SOLUBILITY ENHANCEMENT OF RITONAVIR BY HOT MELT EXTRUSION
Objective: The enhancement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Therefore formulation approaches are being explored to enhance bioavailabi...
ANTIDIABETIC AND ANTIOXIDANT ACTIVITY OF RESVERATROL AND VITAMIN-C COMBINATION ON STREPTOZOTOCIN INDUCED DIABETIC RATS
Objective: Resveratrol and vitamin-C combination was evaluated for its antidiabetic and antioxidant activity in streptozotocin (STZ) induced diabetic rats. Methods: The wistar rats were challenged with a single intra per...
BIOANALYTICAL METHOD DEVELOPMENT OF ATENOLOL IN RAT PLASMA BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY AND TANDEM MASS SPECTROMETRY METHOD: APPLICATION TO PHARMACOKINETIC DRUG-HERB INTERACTION STUDY
Objective: To develop a rapid, simple and sensitive ultra-performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS) method for quantitative estimation of atenolol (ATN) in rat plasma and its application...
TO STUDY THE ROLE OF EXERCISE AND DIETARY MANIPULATION IN OBESE RATS TREATED WITH ORLISTAT
Objective: The present study was undertaken to evaluate the role of exercise and dietary manipulation in obese rats treated with Orlistat.Methods: The study was conducted for 16 weeks. High-fat diet (HFD) was used to ind...
HESPERIDIN HYDROGEL FORMULATION USING PECTIN-CHITOSAN POLYMER COMBINATION
Objective: Hesperidin is flavonoid glycosides that proven to have therapeutic activity to any desease, one of them is colon disease; but, its low solubility (< 100 mg/L) makes small absosption inside the body so it ne...