[b] Cobalt (II) Complexes of ONO donor Schiff bases and N, N donor Ligands: Synthesis, Characterization, Antimicrobial and DNA binding Study[/b]
Journal Title: International Journal of Research in Chemistry and Environment (IJRCE) - Year 2013, Vol 3, Issue 2
Abstract
The mixed –ligand complexes MLA of cobalt(II) with various Schiff bases derived from 4-[i]aminoantipyrine and 3-ethoxy /3-methoxy/5-nitro/5-chloro/5-bromo salicylaldehyde as ONO donor ligands(L) Viz., L1=2,3–dimethyl-1-phenyl-4-(3-ethoxy-2-hydroxybenzylideneamino)-pyrazol-5-one L2 = 2,3–dimethyl-1-phenyl-4-(-2-hydroxy-3-methoxy benzylideneamino)-pyrazol-5-one,L3=2,3–dimethyl-1-phenyl-4-(-2-hydroxy-5-nitro benzylideneamino)-pyrazol-5-one,L4=2,3–dimethyl-1-phenyl-4-(5-chloro-2-hydroxybenzylideneamino)-pyrazol-5-one,L5=2,3-dimethyl-1-phenyl-4-(5- and A= 2,2 –bipyridine(bpy) as N,N-donor ligand have been prepared , owing to their biological and other applications. The nature of bonding and geometry of the metal complexes have been deduced from elemental analysis, FT-IR, UV-Vis, 1H-NMR, 13C-NMR, mass spectral studies, magnetic susceptibility and molar conductance measurements. The Schiff bases act as tridentate ligands which coordinate through the azomethine nitrogen, phenolic oxygen and carbonyl oxygen of antipyrine ring. Based on elemental analysis , conductance and spectral studies, six co-ordinated geometry has been assigned for these complexes. Molecular modelling studies were also carried out to confirm the geometries of the complexes.The interaction of the complex [CoII-L4-A] with calf thymus DNA (CT DNA) was studied by absorption spectroscopic method and its binding constant was evaluated. The results suggest an[/i] intercalative interaction of the complex with CT DNA. Biological screening of these complexes found to show significant antimicrobial activity.
Authors and Affiliations
Anupama B , Gyana Kumari C
Keywords
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