Body composition, somatotype and risk of premenopausal breast cancer: a case-control study in Uruguay
Journal Title: Journal of Cancer Research & Therapy - Year 2013, Vol 1, Issue 2
Abstract
In order to analyze detailed anthropometric characterisation for risk of breast cancer (BC) in premenopausal Uruguayan women, a case-control study was carried out at the Pereira Rossell Women’s Hospital, Montevideo, where 253 incident BC cases and 497 frequency-matched healthy controls were interviewed on menstrual and reproductive story, and a series of body measurements were performed to calculate body composition and somatotype. Odds ratio (OR’s) coefficients were taken as estimates of relative risk derived from unconditional logistic regression. Results show a positive association for the fat fraction (OR for highest quartile =4.19, 95% CI (95% Confidence Interval) 2.70-6.50) as well as for the fat-to-muscle ratio (OR=4.68, 95% CI 2.98-7.36). Muscle fraction was inversely associated with risk (OR=0.53 95% CI 0.36-0.78). High endomorphism was the only somatotype variable associated to the disease risk (OR=1.69, 95% CI 1.13-2.54), however, losing its association when fat amount was included in the regression model. Stratified analyses by body mass index (BMI) levels, bone weight, age groups and number of live births also showed risk increases for the highest fat fractions, displaying significant linear trends. Albeit most of the literature reports a putative slight protective effect for a high BMI in premenopausal women, our results suggest that fat fraction, amount and distribution might play a role as predisposing factors for premenopausal BC.
Authors and Affiliations
Ronco AL, De Stefani E, Deneo-Pellegrini H
Keywords
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- EP ID EP550557
- DOI 10.14312/2052-4994.2013-12
- Views 47
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