Body composition, somatotype and risk of premenopausal breast cancer: a case-control study in Uruguay
Journal Title: Journal of Cancer Research & Therapy - Year 2013, Vol 1, Issue 2
Abstract
In order to analyze detailed anthropometric characterisation for risk of breast cancer (BC) in premenopausal Uruguayan women, a case-control study was carried out at the Pereira Rossell Women’s Hospital, Montevideo, where 253 incident BC cases and 497 frequency-matched healthy controls were interviewed on menstrual and reproductive story, and a series of body measurements were performed to calculate body composition and somatotype. Odds ratio (OR’s) coefficients were taken as estimates of relative risk derived from unconditional logistic regression. Results show a positive association for the fat fraction (OR for highest quartile =4.19, 95% CI (95% Confidence Interval) 2.70-6.50) as well as for the fat-to-muscle ratio (OR=4.68, 95% CI 2.98-7.36). Muscle fraction was inversely associated with risk (OR=0.53 95% CI 0.36-0.78). High endomorphism was the only somatotype variable associated to the disease risk (OR=1.69, 95% CI 1.13-2.54), however, losing its association when fat amount was included in the regression model. Stratified analyses by body mass index (BMI) levels, bone weight, age groups and number of live births also showed risk increases for the highest fat fractions, displaying significant linear trends. Albeit most of the literature reports a putative slight protective effect for a high BMI in premenopausal women, our results suggest that fat fraction, amount and distribution might play a role as predisposing factors for premenopausal BC.
Authors and Affiliations
Ronco AL, De Stefani E, Deneo-Pellegrini H
Keywords
Related Articles
- EP ID EP550557
- DOI 10.14312/2052-4994.2013-12
- Views 59
- Downloads 0
Primary peritoneal serous papillary carcinoma (PSPC) involving ovary and colon: Management and Treatment
We present a case report of a 47-year-old woman who was admitted to our University-Hospital following diagnosis of pelvic mass. Abdominal examination revealed a tender, palpable mass on the right iliac region. At the gyn...
In vitro and in vivo evaluation of tubulin inhibitors with non-small cell lung cancer pre-clinical models
Synthetic small molecule tubulin inhibitors have many advantages as novel anti-cancer agents compared to the current tubulin inhibitors generated from natural products. Our previous studies led to the design and synthesi...
miRNA array analysis determines miR-205 is overexpressed in head and neck squamous cell carcinoma and enhances cellular proliferation
MicroRNAs (miRNAs) play a critical role in cell cycle and pro-survival signal regulation. Consequently, their deregulation can enhance tumorigenesis and cancer progression. In the current investigation, we determined whe...
Outcomes of social support programs in brain cancer survivors in an Australian community cohort: a prospective study
This study evaluated the impact of social support programs on improving cancer related disability, neuro-cognitive dysfunction and enhancing participation (quality of life (QoL), social reintegration) in brain tumour (BT...
Cancer estimation of incidence and survival in Algeria 2014
Cancer is one of the major public health problems in Algeria. In the last 25 years, a significant increase in the incidence of the major types of cancers has been observed in both sexes. Moreover, the 5-year survival rat...