Bone Mineral Density among Lean Type II Diabetes Mellitus Patients-A Cross-sectional Comparative Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 3
Abstract
ABSTRACT Introduction: In case of diabetes mellitus, the pathological process behind fragility of the bone are complex. This process is found to be mediated by various factors like hyperglycaemia, oxidative stress and the accumulation of products of glycation. Aim: To study bone mineral density in lean diabetics and to compare with normal population. Materials and Methods: The present study was undertaken as a cross-sectional comparative study among 60 participants (30 cases of lean diabetics and 30 normal controls). The convenient sampling technique was done to select study participants and the study was carried out during the period from January 2015 to December 2016. Patients who were already a known case of Type 2 diabetes mellitus or newly diagnosed to have Type 2 diabetes mellitus whose BMI was <18.5 kg/m2 were considered as cases. Chi-square test was used for finding a statistically significant difference in proportions; Independent student t-test was used for finding the statistically significant difference between means; Pearson’s correlation coefficient was estimated for finding linear association between two continuous variables; a p-value <0.05 was considered to be statistically significant. Results: On comparison of cases with controls no statistically significant differences were observed between the two groups in terms of age, waist-hip ratio and BMI (p-value >0.05). Bone mineral density parameters were found to be significantly lower among lean diabetes mellitus patients. HbA1C was found to negatively correlate with that of bone mineral density. Conclusion: Osteopenia and osteoporosis, characterised by low bone mineral density values were found to be highly prevalent among lean diabetics.
Authors and Affiliations
Deepak Kumar Garg, Manoj Kumar Dutta
Keywords
Related Articles
- EP ID EP581890
- DOI 10.7860/JCDR/2019/38179.12665
- Views 97
- Downloads 0
Absence of Posterior Triangle: Clinical and Embryological Perspective
Sternocleidomastoid (SCM) and Trapezius (TM) muscle present in the cervical region serves as an important landmark in forming boundaries of posterior triangle of neck. This case reports a continuous muscle sheet obscurin...
Ano-Genital Warts and HIV Status– A Clinical Study
Introduction: Ano-Genital Warts (AGW) like other Sexually Transmitted Diseases (STD) is associated with Human Immunodeficiency Virus (HIV) infection. This study of AGW was done in HIV positive and HIV negative patients....
A Prospective Study of Adverse Drug Reactions in Patients with Bipolar Disorder in Psychiatry Outpatient Department of a Tertiary Care Hospital
Introduction: Bipolar disorder is a chronic, debilitating psychiatric disorder. Mood stabilizers and atypical antipsychotics are first line drugs for bipolar disorder. They have significant adverse effects. Aim: The stud...
Self-Image and Quality of Life among Head and Neck Cancer Patients
ABSTRACT Introduction: Cancers affecting the parts of head and neck hugely impact the patients. Among Head and Neck Cancer (HNC) patients, the visible signs and symptoms of the disease or the side effects of treatment mo...
Role of Glutathione S-Transferase in Coronary Artery Disease Patients with and Without Type 2 Diabetes Mellitus
Introduction: Glutathione S – transferase (GST) is an important enzyme in detoxification and helps in lowering oxidative stress. It is speculated that this enzyme is induced under conditions of oxidative stress as a prot...