Bone mineral density in children with idiopathic nephrotic syndrome
Journal Title: Jornal de Pediatria - Year 2017, Vol 93, Issue 2
Abstract
Objectives To assess bone mineral density (BMD) in children with idiopathic nephrotic syndrome (NS) and normal glomerular filtration rate (GFR). Methods Cross-sectional case–control study carried out on 50 children: 25 cases of NS (16 steroid-sensitive [SSNS] and nine steroid-resistant [SRNS] under follow up in the pediatric nephrology unit of Menoufia University Hospital, which is tertiary care center, were compared to 25 healthy controls with matched age and sex. All of the participants were subjected to complete history taking, thorough clinical examination, laboratory investigations (serum creatinine, blood urea nitrogen [BUN], phosphorus [P], total and ionized calcium [Ca], parathyroid hormone [PTH], and alkaline phosphatase [ALP]). Bone mineral density was measured at the lumbar spinal region (L2–L4) in patients group using dual-energy X-ray absorptiometry (DXA). Results Total and ionized Ca were significantly lower while, serum P, ALP, and PTH were higher in SSNS and SRNS cases than the controls. Osteopenia was documented by DXA scan in 11 patients (44%) and osteoporosis in two patients (8%). Fracture risk was mild in six (24%), moderate in two (8%), and marked in three (12%) of patients. Conclusion Bone mineralization was negatively affected by steroid treatment in children with NS.
Authors and Affiliations
Mahmoud Ahmed El-Hawy
Keywords
Related Articles
- EP ID EP508693
- DOI 10.1016/j.jped.2016.05.010
- Views 62
- Downloads 0
Day care attendance during the first 12 months of life and occurrence of infectious morbidities and symptoms
Objective To investigate the occurrence of infectious morbidities according to day care attendance during the first year of life. Methods This was a cross-sectional analysis of data from the 12-month follow-up of a mediu...
Prevalence of metabolic syndrome-like in the follow-up of very low birth weight preterm infants and associated factors
Objective To assess the prevalence of metabolic syndrome-like symptoms in a population of preterm infants with very low birth weight (<1500g) at 2 years of corrected age and identify the occurrence of associated risk fac...
Sepsis-associated acute kidney injury – is it possible to move the needle against this syndrome?
On the one hand, sepsis is the leading cause of non-trauma related death in pediatric patients across the world, in both developed and developing nations.1 On the other hand, epidemiologic data demonstrate the independen...
Evaluation of factors associated with vertical HIV-1 transmission
Objective To compare the prevalence and factors associated with vertical transmission of human immunodeficiency virus 1 (HIV–1) among pregnant women treated in the periods of 1998–2004 and 2005–2011 in a reference servic...
Sleep and electronic media exposure in adolescents: the rule of diminishing returns
Electronic media has now pervasively invaded our households and one group of individuals that has clearly been a major and early adopter of such disruptive technology is the adolescent age group. The issue of screen and...