Bone mineral density in obese children with prediabetes
Journal Title: Ege Tıp Dergisi - Year 2018, Vol 57, Issue 2
Abstract
Aim: The aim of this study was to evaluate the relationships between bone mineral density (BMD) vs metabolic risk factors in obese adolescents with prediabetes. Materials and Methods: A total of 131 obese children and adolescents, aged 6-18 years of age were enrolled the study. Prediabetes was determined by a fasting blood glucose level of ≥100 to 125 mg/dL or 2-hour oral glucose tolerance test value of ≥140 to 199 mg/dL. Five patients who were diagnosed as having type 2 diabetes were excluded and remaining participants were classified as normal glucose tolerance (NGT) and prediabetic. BMD was measured on calcaneus using quantitative ultrasound. BMD and metabolic parameters were investigated and compared in these two groups. Results: There was no significant difference in BMD between children and adolescents with prediabetes (n=37) or NGT (n=89). The parameters of prediabetes did not affect BMD and these results did not change when we adjusted for weight, height, age, sex, pubertal status. The multivariate linear regression analysis revealed that the only independent factor associated with higher BMD was higher body mass index (BMI) (OR=0.007, 95%CI: 0.002-0.013, p=0.013). No significant associations were found between BMD and waist circumference or biochemical measurements. Conclusion: Plasma glucose within the prediabetic range is not associated with bone mineral density in obese children. Thus, the positive association of BMI with BMD may be by means of alternative pathways.
Authors and Affiliations
Ala Üstyol, Mehmet Emre Atabek
Keywords
Related Articles
- EP ID EP459929
- DOI -
- Views 93
- Downloads 0
Evaluation of 5-year results of the inversion of inv(16) CBFBETA-MYH11 with real time RT-PCR in patients prediagnosed as AML
Aim: In this study, it was aimed to evaluate the analysis of inv16 blood and bone marrow samples quantitively by reverse transcriptase polymerase chain reaction (RT-PCR) method of 402 patients (322 adult, 80 children) pr...
ZNF304 gen ifadesinde artış ve CXCR4’de azalma ile prostat kanserinde anoikis değişebilir
Amaç: Prostat kanser hücre hattı (DU145) ve prostat normal epitel hücre hatları (RWPE) arasında anoikis mekanizmasını arttıracak veya inhibe edebilecek genlerin analizini yapmak ve kanser gelişiminde olası rolünü incelem...
Osteoporozda farmakolojik tedavi
Osteoporoz tedavisinde kullanılan ajanlar genellikle iyi tolere edilir ve oldukça etkindirler. Bisfosfonatlar ve RANKL inhibitörü denosumab gibi antirezorptifler en sık kullanılan osteoporoz ilaçlarıdır. Bu ajanlar postm...
Bilateral anterior shoulder dislocation: A case report and a review of the literature
Dislocation is more often encountered due to multilateral mobility of the shoulder joint, its anatomic characteristics, and its being more exposed to traumas. Shoulder dislocations are often anterior and unilateral; thou...
Squamous cell carcinoma arising from mature cystic teratoma fistulised to sigmoid colon
Mature cystic teratoma is the most common germ cell tumor of the ovary that generally occurs during reproductive period. Although mature cystic teratoma is a benign tumor, rarely (1-2%) it may show malignant transformati...