Bone Mineral Density: Relationship with Serum Osteoprotegerin, Biophysical Profile and Menopausal Status in Indian Women
Journal Title: International Journal of Anatomy Radiology and Surgery - Year 2018, Vol 7, Issue 4
Abstract
Introduction: The Osteoprotegerin (OPG) cytokine network has been found to control bone homeostasis and is implicated in increased skeletal resorption, including several forms of osteoporosis. Aim: To establish the relationship of Bone Mineral Density (BMD) with serum Osteoprotegerin levels and the biophysical profile (waist to hip ratio and body mass index) and also to correlate it with menopausal status and risk of osteoporosis. Material and Methods: A case-control study was conducted on 110 non-pregnant subjects: 40 perimenopausal, 40 post-menopausal women and 30 women in the reproductive age group. Bone mineral densitometry by Quantitative Computerized Tomography (QCT) at lumbar spine, Waist-to-hip (W:H) ratio and Body Mass Index (BMI) were computed. Results: Independent student’s t-test and Karl Pearson’s correlation coefficient analyzed the parameters under study. Standard unimodal distribution curve determined the cut-off value of Osteoprotegerin for screening of osteoporosis risk. In the peri-menopausal age group (40-55 years), there were significant correlations of BMD with age and BMI (p=0.0857; p=0.458). The postmenopausal group (50-70 years) had significant correlations of OPG with age (p=0.030), W:H ratio (p=0.002) and BMI (p=0.005). An OPG concentration of 17.9 pmol/L could predict osteoporosis in postmenopausal women. BMD detected the maximum number of osteoporotic and osteopenic subjects within the postmenopausal group while least were encountered in the normal group. Conclusion: Osteoporosis was encountered in 60% of post-menopausal and 40% of peri-menopausal patients due to low oestrogen levels. Maximum derangement of BMD, waist to hip ratio and BMI were seen in overweight women. The significant correlations of BMD with BMI may be utilized for assessing osteoporosis in menopausal women.
Authors and Affiliations
Sarika Rachel Tigga, Anita Tuli, Shashi Raheja, Abha Singh, Vikas Choudhary, Sandeep Saluja
Keywords
Related Articles
- EP ID EP533605
- DOI 10.7860/IJARS/2018/37877:2435
- Views 122
- Downloads 0
Highlighting the Outcome of Single Stage Multilevel Soft Tissue Surgery in Patients of Cerebral Palsy with Static Contracture (s)
Introduction: The impact of single stage multilevel soft tissue surgeries needs to be evaluated in spastic cerebral palsy children to offer a convenient treatment option for the majority of children who are lost to follo...
Appearance of Renal Cysts in Adult Human Cadavers
Introduction: The cysts present on the kidney are generally developed due to either genetic or pathological factors. Such lesions of kidneys are usually found to be filled with fluid. An Autosomal Dominant Polycystic Kid...
Transient Osteoporosis of Hip Presenting as Stress Fracture
Transient Osteoporosis of Hip (TOH) is a rare idiopathic, reversible, rapidly developing and spontaneously resolving osteoporosis, a diagnosis of exclusion. It is seen more commonly in middle aged men, though also seen i...
Evaluation of Inferior Alveolar Canal and its Variations using Cone Beam CT-scan
ABSTRACT Introduction: The knowledge of the precise location of anatomical landmarks such as mandibular foramen, Inferior Alveolar Canal (IAC), mental foramen and the course of the inferior alveolar neurovascular bundle...
Imaging Appearances in a Case of Tumoral Calcinosis
ABSTRACT Tumoral calcinosis is an uncommon entity characterised by calcified para-articular masses as demonstrated most often on radiographs. It can occur at any age and is inherited as an autosomal dominant mode that ha...