Bone Mineral Density: Relationship with Serum Osteoprotegerin, Biophysical Profile and Menopausal Status in Indian Women
Journal Title: International Journal of Anatomy Radiology and Surgery - Year 2018, Vol 7, Issue 4
Abstract
Introduction: The Osteoprotegerin (OPG) cytokine network has been found to control bone homeostasis and is implicated in increased skeletal resorption, including several forms of osteoporosis. Aim: To establish the relationship of Bone Mineral Density (BMD) with serum Osteoprotegerin levels and the biophysical profile (waist to hip ratio and body mass index) and also to correlate it with menopausal status and risk of osteoporosis. Material and Methods: A case-control study was conducted on 110 non-pregnant subjects: 40 perimenopausal, 40 post-menopausal women and 30 women in the reproductive age group. Bone mineral densitometry by Quantitative Computerized Tomography (QCT) at lumbar spine, Waist-to-hip (W:H) ratio and Body Mass Index (BMI) were computed. Results: Independent student’s t-test and Karl Pearson’s correlation coefficient analyzed the parameters under study. Standard unimodal distribution curve determined the cut-off value of Osteoprotegerin for screening of osteoporosis risk. In the peri-menopausal age group (40-55 years), there were significant correlations of BMD with age and BMI (p=0.0857; p=0.458). The postmenopausal group (50-70 years) had significant correlations of OPG with age (p=0.030), W:H ratio (p=0.002) and BMI (p=0.005). An OPG concentration of 17.9 pmol/L could predict osteoporosis in postmenopausal women. BMD detected the maximum number of osteoporotic and osteopenic subjects within the postmenopausal group while least were encountered in the normal group. Conclusion: Osteoporosis was encountered in 60% of post-menopausal and 40% of peri-menopausal patients due to low oestrogen levels. Maximum derangement of BMD, waist to hip ratio and BMI were seen in overweight women. The significant correlations of BMD with BMI may be utilized for assessing osteoporosis in menopausal women.
Authors and Affiliations
Sarika Rachel Tigga, Anita Tuli, Shashi Raheja, Abha Singh, Vikas Choudhary, Sandeep Saluja
Keywords
Related Articles
- EP ID EP533605
- DOI 10.7860/IJARS/2018/37877:2435
- Views 117
- Downloads 0
The Reliability and Reproducibility of Patellotrochlear Index as a Measure of Patellar Instability in Indian Population
Introduction: The knee joint is one of the most used and abused joint of the body and hence knee discomfort and pain is one of the primary complaint of patients presenting to the orthopaedic out-patient department. There...
Estimation of Length of Femur from its Proximal Segment in Maharashtrian Population
ABSTRACT Introduction: Stature is an important parameter in identification of an individual. It can be calculated from length of long bones especially femur and tibia. Bony markers such as head and neck of femur can used...
Lipoid Proteinosis in a Young Female: A Case Report
Lipoid proteinosis or Urbach-Wiethe disease is a rare autosomal recessive disorder. It is characterized by progressive deposition of hyaline substance in the mucous membranes, skin and internal organs. It is characterize...
Our Experience in Managing A Rare Case of Sporadic Bilateral Juvenile Otosclerosis
Otosclerosis constitutes a focus of localized new spongy bone formation in the labyrinthine capsule. This progressive conductive type hearing loss is a disease of young and middle aged adults. Studies have shown that the...
Anatomical Variations in the Division and Innervation of the Sciatic Nerve with its Clinical Consequences
ABSTRACT Introduction: Commonly encountered peripheral nerve in emergency, trauma, routine surgical medical practice and neurology is Sciatic Nerve (SN). Its vulnerability to injury is because of its thickness and long c...