Bone regeneration by means of bioactive glasses – an experimental study
Journal Title: Medicine in Evolution - Year 2017, Vol 0, Issue 4
Abstract
In the last years, alloplastic materials became more and more studied. They are in needed for bone defect augmentation treatments, whether they are congenital or have occurred after traumatic injuries, tumor resection, or regarding implant restoration of the alveolar crest. The main advantage of alloplastic materials is that they have no risk of infection dissemination, being completely synthetic. This experimental animal study aims to follow the type of bone regeneration after preforming standardized bone defects and augmenting them with bioactive glasses. The study involved six New Zeeland white rabbits. The bone defects were produced in the left tibial bone, by drilling five monocortical holes with a small round bur, 1 mm diameter. The defects were augmented with bioactive glasses and they were covered with collagen membranes. The animals were sacrificed after six months and we made a histopatological evaluation. In all cases it can be observed that a partial resorption takes place even to a total resorption of the bioactive glasses granules, their occupying space not being replaced by new bone. Therefore, shallow optical spaces have been created within the cortical bone. The quantity of newly formed bone is significantly reduced, demonstrated also by the small amount of osteoblastic cells present.
Authors and Affiliations
Neculae I. I. , Anghelescu V. M. , Zurac S. , Dinca O. , Vladan C. , Bucur A.
Keywords
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