Bone Turnover Markers in Post Menopausal Osteoporosis- A Case Control Study
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 2
Abstract
Osteoporosis is a major health problem worldwide and is projected to increase exponentially due to aging. In post-menopausal women rapid bone loss occurs due to hormonal factors leading to enhanced bone fragility and consequent increased risk of fractures. Measurement of serum and urinary bone turnover markers provide valuable information for diagnosis and monitoring of metabolic bone disease. Bone resorption marker urinary hydroxyproline and bone formation markers serum and urinary calcium, phosphorous were analysed to assess the skeletal turnover in the present study. Significantly increased excretion of hydroxyproline and calcium in urine, significant decrease in serum calcium and increase in serum phosphorous was observed in post-menopausal women when compared to controls. Hence this study suggests that simple, common bio-chemical markers can be used to assess the bone turnover and the risk of developing osteoporosis and fractures in postmenopausal women.
Authors and Affiliations
Madhavi Latha. N
Keywords
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