Bortezomib-Associated Severe Orthostatic Hypotension and Hyponatremia
Journal Title: Turkish Journal of Hematology - Year 2012, Vol 29, Issue 3
Abstract
To the Editor, The most frequent side effects of bortezomib are fatigue, hematologic toxicity with cytopenias, and peripheral neuropathy, whereas postural hypotension and hyponatremia are less common late side effects [1,2]. Hyponatremia is a potentially fatal complication that has been reported in 3%-22% of patients treated with bortezomib, and has been attributed to direct bortezomib toxicity and syndrome of inappropriate anti-diuretic hormone secretion (SIADH) [3]. The direct toxicity of bortezomib might be dose dependent [1]; however; there is insufficient evidence to support this mode of action. We think hyponatremia in the presented patient was due to direct bortezomib toxicity, as it resolved following cessation of bortezomib and saline infusion.
Authors and Affiliations
Elif Suyanı, Zeynep Akı, Gülsan Sucak
Keywords
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- EP ID EP137496
- DOI 10.5505/tjh.2012.90377
- Views 63
- Downloads 0
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