Brain Dialysis (Microdialysis)
Journal Title: International Journal of Practical Nursing - Year 2017, Vol 5, Issue 3
Abstract
Brain dialysis or microdialysis is a minimallyinvasive sampling technique that is used for continuous measurement of free, unbound analyte concentrations in the extracellular fluid of virtually any tissue. Analytes may include endogenous molecules (e.g. neurotransmitter, hormones, glucose, etc.) to assess their biochemical functions in the body, or exogenous compounds (e.g. pharmaceuticals) to determine their distribution within the body. The microdialysis technique requires the insertion of a small microdialysis catheter (also referred to as microdialysis probe) into the tissue of interest. The microdialysis probe is designed to mimic a blood capillary and consists of a shaft with a semipermeable hollow fiber membrane at its tip, which is connected to inlet and outlet tubing. The probe is continuously perfused with an aqueous solution (perfusate) that closely resembles the (ionic) composition of the surrounding tissue fluid at a low flow rate of approximately 0.15ìL/ min. Once inserted into the tissue or (body) fluid of interest, small solutes can cross the semipermeable membrane by passive diffusion. The direction of the analyte flow is determined by the respective concentration gradient and allows the usage of microdialysis probes as sampling as well as delivery tools. The solution leaving the probe (dialysate) is collected at certain time intervals for analysis.
Authors and Affiliations
I. Clement
Keywords
Related Articles
- EP ID EP469792
- DOI 10.21088/ijpn.2347.7083.5317.8
- Views 97
- Downloads 0
The Impact of Technology on Nursing Care
While myriad forces are changing the face of contemporary healthcare, one could argue that nothing will change the way nursing is practiced more than current advances in technology. Indeed, technology is changing the wor...
Pemphigus Vulgaris with Toxic Epidermal Necrolysis : A Case Report
Pemphigus vulgaris (PV) is a chronic autoimmune blistering disorders characterized by painful blister formation of the skin and mucous membranes. Although the prevalence of pemphigus vulgaris in children is unknown [1,2]...
Knowledge and Attitude towards Mental Illness among Adults of Selected Urban Community
Background: Attitudes of patients and public towards mental illness and treatment is very influencing factor. A comprehensive review of public attitudes toward mental illness is important to educate the public as well, i...
Descriptive Study of Knowledge Regarding Bio-Medical Waste Management among Hospital Attendants
The aim of the study is to evaluate the knowledge of bio-medical waste management among hospital attendants at AIIMS Patna. The objective of the study is to assess the level of knowledge of hospital attendants regarding...
Nursing Process: Functional Health Pattern
The nurse assess the patient s’ functional health pattern to identify patients strengths in function and to determine if dysfunctional health patterns and/or potential dysfunctional pattern exist. A day’s functional heal...