Brain nitric oxide synthases in the interleukin-1β-induced activation of hypothalamic-pituitary-adrenal axis.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6
Abstract
Interleukin-1β (IL-1β), the major cytokine involved in activation of hypothalamic-pituitary-adrenal (HPA) axis modulates both central and peripheral components regulating HPA activity. The role of nitric oxide (NO) generated by neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS) in brain structures involved in HPA axis regulation has not been elucidated. The aim of the study was to assess the receptor selectivity of IL-1β stimulatory action on HPA axis and to determine the involvement of nNOS and iNOS in this stimulation.
Authors and Affiliations
Anna Gądek-Michalska, Joanna Tadeusz, Paulina Rachwalska, Jadwiga Spyrka, Jan Bugajski
Keywords
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