Breast cancer, bone and marrow metastases
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2013, Vol 30, Issue 2
Abstract
A 62-year-old woman was admitted in the Orthopedics Department, due to a recent right hip injury. The X-ray revealed a subtrochanteric fracture of the right femur. Her medical history was remarkable for an episode of mastitis of right breast four years ago, regular consumption of non-steroidal anti-inflammatory drugs (NSAIDs) due to lumbar pain for the last three years, and treatment with oral bisphosphonates during the last year. Multiple osteolytic lesions and few osteosclerotic lesions were prominent in pelvic and spine X-rays. Peripheral blood smear revealed a mild leukoerythroblastic reaction and complete blood counts were as follows: Ht 24.5%, Hb 7.9 g/dL, WBC 8.59×109/L (differential count: neutrophils 86%, myelocytes 2%, metamyelocytes 3%, lymphocytes 7%, monocytes 2%; few circulating erythroblasts) and platelets 209×109/L. The remaining laboratory findings revealed a highly elevated erythrocyte sedimentation rate of 120 mm/h, marked hypergammaglobulinemia (7.3 g/dL; fig. 4), and hypercalcemia (10.6 g/dL). C-reactive protein (CRP) was also elevated (95 mg/L) along with mild elevations in serum alkaline phosphatase (188 U/L versus upper normal limit of 106 U/L), and lactate dehydrogenase (LDH;273 U/L versus upper normal limit of 220 U/L). Regarding the complete blood count and the blood smear, there was prominent mild leukoerythroblastic reaction. A bone marrow aspiration and biopsy was diagnostic.
Authors and Affiliations
A. BILALIS, T. VASSILAKOPOULOS, L. PAPAGEORGIOU, E. KOUTSI, K. PETEVI, G. BOUTSIKAS, P. FLEVARI, V. TELONIS, M. ANGELOPOULOU, J. MELETIS
Keywords
Related Articles
- EP ID EP151429
- DOI -
- Views 59
- Downloads 0
Investigation of anxiety and depression among individuals addicted to substances
OBJECTIVE Investigation of the levels of anxiety and depression among individuals addicted to substances who requested help from a Mental Health Rehabilitation Program. METHOD To conduct this study quantitative method...
Αssociation of multiple sclerosis with monoclonal gammopathy of undetermined<br /> significance<br />
The cases are presented of two patients with monoclonal gammopathy of undetermined significance (MGUS) associated with multiple sclerosis (MS). MGUS is the result of a plasma cell clone escaping normal control. MS is...
The diagnosis of bronchial asthma in elite athletes
Εxercise is one of the most common triggers of bronchospasm. Exercise-induced bronchospasm is a particularly common problem in elite athletes and may have significant impact on their athletic performance. The diagnosis o...
Εpilepsy and art
The sight of a man experiencing an epileptic seizure may create various emotions in an observer, such us annoyance, aversion, fear, embarrassment, curiosity, sympathy or sadness. Because of this, through the centuries ep...
Etiopathogenesis and management of non-cystic fibrosis bronchiectasis
Bronchiectasis is a chronic, inflammatory disease of the bronchi and bronchioles. Its pathogenesis is characterized by a vicious cycle of inflammation provoked by and, simultaneously, predisposing to altered response to...