Abstract

Background Breast carcinoma secondarily involving the uterus is very rare. It usually occurs as a manifestation of widespread disease. There are few case reports available in the English language literature on this seldom seen occurrence. Cases We report 2 cases of breast carcinoma metastatic to the uterus. Patient A was a 47-year-old African American lady admitted for thrombocytopenia. A mammogram done a few weeks prior to admission was reported as BIRADS 4 for the right breast. She had a biopsy done as an inpatient which revealed invasive lobular carcinoma. Due to persistent vaginal bleeding a gynecological consult was requested; accordingly, endometrial curettage was done with pathology reported as metastatic lobular carcinoma of the breast. Further testing confirmed a diagnosis of stage 4 carcinoma of the breast. The patient died two months later. Patient B was a 59-year-old Caucasian lady who was referred to gynecologic oncology for evaluation of post menopausal bleeding. She had a history of stage IIIA, grade 1 lobular cancer in the left breast, in remission for 7 years. A recent CT scan showed an enlarged lobular uterus and irregular cervix. She underwent dilatation and curettage with endometrial biopsy and cervical biopsy. Pathology report showed metastatic breast lobular carcinoma of the uterus. The morphology and immunophenotype of the endometrial samples revealed the neoplastic nature of the endometrial lesions and confirmed their origins from the breast in both cases. Conclusion Atypical bleeding in patients with known breast carcinoma should prompt screening for endometrial metastasis by a gynecologist. Metastasis to the uterus carries a grim prognosis.

Authors and Affiliations