Breath analysis as a diagnostic tool for lung cancer
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2017, Vol 6, Issue 1
Abstract
The early diagnosis of lung cancer is key to effectively treating this common and deadly disease. In this review we consider whether non-invasive breath-based detection of volatile biomarkers offers a means to screen populations for the presence of the disease. We find that many potential volatile cancer biomarkers have been reported, including some in multiple studies, and that many are biologically plausible. The field lacks prospective studies, however, which are needed to determine whether such markers are of use for the detection of lung cancer in its pre-symptomatic stages. This,and a lack of knowledge about the various endogenous and exogenous sources of such potential cancer markers, hampers the clinical development of this testing paradigm despite its undeniable appeal. Further work is therefore required before any firm conclusions can be drawn regarding the utility of breath analysis for the diagnosis of lung cancer.
Authors and Affiliations
Randa H. Babgi| Northern Ontario School of Medicine and Department of Biology, Lakehead University, Thunder Bay Ontario, Canada., Brian M. Ross| Northern Ontario School of Medicine and Department of Biology, Lakehead University, Thunder Bay Ontario, Canada.
Keywords
Related Articles
- EP ID EP3820
- DOI -
- Views 381
- Downloads 37
TRAMADOL - A LOCAL ANAESTHETIC WITH A DIFFERENCE
Objectives: The synthetic opioid, tramadol is useful in a wide range of acute and chronic pain states. Of late, in addition to its systemic action, the local anaesthetic effect of tramadol on peripheral nerves has been s...
OPTIMIZATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) OF REPAGLINIDE USING D-OPTIMAL MIXTURE EXPERIMENTAL DESIGN
Repaglinide, which is widely used in treatment of type 2 diabetes, is practically insoluble in water with low bioavailability (about 50%) and poor absorption characteristics in upper intestinal tract. Self-nanoemulsifyi...
PERINATAL OUTCOMES ASSOCIATED WITH MECONIUM STAINED NON VIGOROIUS BABIES IN A TERTIARY CENTRE OF UTTARAKHAND (INDIA)
We examined the perinatal outcomes in singleton pregnancies associated with meconium-stained amniotic fluid (MSAF) in non vigorous neonates.The study was performed during one year (2012-2013) in new borns admitted at o...
Validation of Reference Genes for Reliable Gene Expression Study in Human Glioblastoma Multiformeand Neural Stem Cell Lines
Glioblastoma multiforme (GBM) is the most deadly malignant brain tumor in adults. GBM has a histologically heterogeneous group of neoplastic cells which are postulated to be the mediator of anti-cancer therapy resistance...
COMPARISON BETWEEN COBAS E411 AND ICT IN DIAGNOSIS OF HEPATITIS B VIRUS
Background: Hepatitis B is one of the world’s most common and serious infectious diseases. It is estimated that more than one third of the world’s population has been infected with hepatitis B virus Differentiation betwe...