Brief Report: Renal Failure on Melanoma an Experimental Overview of Melanin and ImmunoComplexes Deposition
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 19, Issue 4
Abstract
Background: Metastatic melanoma progression induces renal insufficiency, with a sequence of infections due to immunological involvement, ascites, hypertension and subsequent hypotension associated with sepsis. The aim of this study was to evaluate biochemical renal damage markers in an experimental model of melanoma in mice. Methods: Animals were divided into three groups: control, B16F10 (melanoma) cell implantation and animals receiving daily injections of melanoma culture supernatant. It was evaluated in two periods ten and twenty days. Renal function were evaluated by urinary markers. Interleukin-18 were evaluated by ELISA. Results: There was loss of renal function in mice with melanoma evaluated by urinary markers; the daily application of melanin and other factors derived from the melanoma supernatant did not alter the renal function. Melanoma bearing mice, after 20 days, presented a significantly value of Interleukin-18. Conclusion: Renal function is gradually changed in melanoma and is probably associated with immune complexes than circulating melanin.
Authors and Affiliations
Bruno Campos Fontoura, Bruno Ribeiro Cruz, Leandro Cavalcante Lipinski, Angelo César D Urso Panerari, Daniel Fernandes, Giovani Marino Favero
Keywords
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- EP ID EP622504
- DOI 10.26717/BJSTR.2019.19.003345
- Views 154
- Downloads 0
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