Brown tumour revealed: A literature review with a case study
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 4
Abstract
The mandibular hyperparathyroid brown tumour is considered a rare metabolic disorder, also known as mandibular osteoclastome, therefore its therapy is not well defined yet; This lesion is triggered by the excess of the production of PTH parathyroid hormone, which are directly linked to mechanisms of control of levels of calcium, phosphorus and vitamin D, which confers the lesions the aspect of numerous osteoclastic cells, circumscribed and richly vascularised Which causes their reddish-brown coloration, individuals affected by this disorder show signs and symptoms of weakness, nausea, fatigue, anorexia, excessive thirst, polyuria, constipation and consequently depression, the purpose of this study is to perform a literature review by describing the case of mandibular brown tumour, explaining the conduct performed according to the case by clinical, laboratory analysis and image studies that guided the case.This disorder, called brown tumour, has its determinant a metabolic bone disarray caused by the excess production of parathyroid hormone, which is produced by the four parathyroid glands located posterior to the thyroid gland, which are responsible for the control of phosphorus (P), calcium (Ca) and vitamin D; The level of calcium present in the blood is considered a triggering factor of the disorder by the release and production of this hormone. Shetty “the hyperparatiroidism HPT is a disease in which there may be a complex, of biochemical anatomic and clinical abnormalities”. Therefore the Brown Tumor has its histopathological complexity described as multiple adenomas, numerous osteoclastic cells, of cystic format, and separated by a highly vascularized tissue which will confer the lesion a dark red or brownish coloration which characterizes its nickname. Some of the signs and symptoms observed in this disorder are fatigue, nausea, weakness, anorexia, excessive thirst, polyuria, constipation, pain, swelling and frequent urination. In severe cases, may present kidney stones, loss of bone mass and fractures, mental confusion and consequent depression.
Authors and Affiliations
Marcelo Pinto
Keywords
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- EP ID EP581460
- DOI 10.26717/BJSTR.2017.01.000587
- Views 171
- Downloads 0
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