Buccal Mucosa Squamous Cell Carcinoma: Analysis of ECOG Performance Status and its Association with Sociodemographic, Socioeconomic, Clinico-Pathologic Factors and Overall Survival
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 3
Abstract
ABSTRACT Introduction: Despite, progress in cancer therapeutics, survival remains very poor due to various factors. However, treatment decision making is an important factor for a better survival outcome. Aim: To evaluate Eastern Cooperative Oncology Group Performance Status (ECOG-PS) in buccal mucosa squamous cell carcinoma and its association with sociodemographic, socioeconomic, clinicopathologic factors and overall survival. Materials and Methods: This prospective study was conducted in the Regional Cancer Centre, Tamil Nadu between March 2013 and January 2016. Chi-square test and binary logistic regression were performed to evaluate the association between the covariates and ECOG-PS. Further, Kaplan-Meier and log-rank test were used for survival analysis. All statistical significance was set at p<0.05. Results: A total of 198 subjects which comprised 125 (63.1%) male and 73 (36.9%) female. In the study, demographic characteristics (Gender, Age, Body mass index and Risk habits) were failed to show the significance whereas socioeconomic status (p≤0.001) and clinicopathological features like cell differentiation (p=0.034), TNM stage (p≤0.001), lymph node status (p≤0.001) and metastasis (p≤0.001) exhibited significant association at p<0.05. Further, the presence of lymph node and metastasis had 2.27 fold and 1.053 fold risk of disease recurrence/death of subjects than negative lymph node and metastasis respectively. All the subjects were followed for an average of 18 months. Of 198 subjects, 24 (12.1%) reported recurrence and 7 (3.5%) were identified with disease-specific death and the rest of 167 (84.4%) were alive at last follow-up. The estimated overall survival rate was 48% and the study revealed a lower survival outcome of poor ECOG-PS than good ECOG-PS (p=0.046, p<0.05). Conclusion: The present study concludes that the subject’s physical performance score using ECOG-PS scale at diagnosis may help to identify aggressiveness of the disease and may help medical care requirements, specific therapeutic and rehabilitative interventions.
Authors and Affiliations
Padma Ramasamy, Amitkumar Kalaivani, Sivapatham Sundaresan
Keywords
Related Articles
- EP ID EP580903
- DOI 10.7860/JCDR/2019/31698.12688
- Views 93
- Downloads 0
A Case of Severe Hyperkalemia Presenting with No Significant ECG Changes
ABSTRACT An increase in serum potassium levels is followed by progressively severe electrophysiological derangements in cardiac impulse generation and conduction, which are reflected in the electrocardiogram (ECG). Sever...
Non Lactational Breast Abscess due to Actinomyces odontolyticus: First Case Report from Asia
ABSTRACT Actinomycosis is a chronic infection caused by the aerotolerant anaerobe, Actinomyces spp., characterised by the formation of abscess, draining sinuses and tissue fibrosis. Primary actinomycosis of the breast is...
Lipoma of the Parotid Gland-A Rare Entity
ABSTRACT Lipomatous tumours are the most commonly encountered benign neoplasms of mesenchymal origin. The lipomas consisting entirely of mature fat are the most common soft tissue tumour of the body occurring predominant...
Does Training of Sensory Processing Helps in Improving Motor Execution in Children with Cerebral Palsy?
Letter to Editor
Magnetic Resonance Spectroscopy of Giant Cell Tumour of Bone
ABSTRACT Introduction: Usefulness of proton Magnetic Resonance Spectroscopy (MRS) in evaluating and differentiating benign from malignant bone tumours is well known and has been reported in literature. Role of magnetic r...