Burn Wound Healing Potential of Honey, Sandal Wood, Calendula and Cooling with Tap Water-A Comparative Study on Wistar Rats
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 10
Abstract
ABSTRACT Introduction: Burn injury is always associated with high morbidity and mortality depending on the percentage of burns. Slow wound healing, infection, pain, and hypertrophic scarring continue to remain a major challenge to the clinicians in the management of it. Aim: To study the burn wound healing potential of Honey, Sandal wood, Calendula and cooling with tap water on wistar rats. Materials and Methods: Fifty four rats of either sex weighing 180-200 gm were (n=6) divided into nine groups which were-Group 1: Control (Ointment base), Group 2: Honey, Group 3: Sandalwood paste, Group 4: Calendula ointment, Group 5: Honey and Sandalwood paste (H+S), Group 6: Honey and Calendula ointment (H+C), Group 7: Honey and sandalwood and Calendula (H+C+S), Group 8: cooling with tap water and Group 9: 1% Silver sulfadiazine. Rats were anaesthetised with thiopental sodium and placed in supine position touching shaved back to the bottom of tray containing hot water 90°C for 6 seconds. The animals were resuscitated with 5 mL of normal saline intra-peritoneally. Drug treatment was given according to groups topically for 25 days. Wound contraction was expressed as reduction in percentage of the original wound size. The parameters observed were epithelisation period and percentage of wound contraction. Statistical analysis was done with One-way ANOVA followed by Tukey’s test. Results: Significant improvement in wound contraction was seen in all the groups except in control and H+C+S group. Epithelisation started early in H+S combination group, significant (p<0.001) improvement with complete healing and hair growth was seen. Results of Calendula, Honey and Tap water groups were comparable with silver sulfadiazine. Conclusion: Honey, sandalwood, calendula and cooling with tap water was effective in reducing the initial damage. Honey and Sandalwood combination showed better effect with complete burn wound healing.
Authors and Affiliations
Jayshree Shriram Dawane, Anand Biradar, Ketan Vaidya, Ashutosh Sharma, Madhura Bhosale, Vijaya Anil Pandit
Keywords
Related Articles
- EP ID EP525975
- DOI 10.7860/JCDR/2018/36971.12125
- Views 35
- Downloads 0
Should the Urologist Demarcate the Surgical Specimen after Radical Prostatectomy
ABSTRACT Introduction: Although the literature about prostate cancer is vast in tracking discussion about diagnosis and treatment of prostate cancer, there are few publications about the best form of surgical specimen pr...
Ceftriaxone Induced Hypersensitivity Reactions Following Intradermal Skin Test: Case Series
The incidence of cephalosporin induced hypersensitivity reactions in non-penicillin allergic patients is about 1.7% and in penicillin allergic patients it is about 3-5%. Infact, cephalosporins are considered as the first...
Analysis of Risk Factors and Outcome of Renal Failure in Benign Prostatic Hyperplasia
ABSTRACT Introduction: Benign Prostatic Hyperplasia (BPH) is one of the most common diseases of aging men, affecting 50% by 60 years of age and increasing to 90% by ninth decade of life. A small percentage of men with ob...
Role of Neck Dissection in Clinical T3 N0 M0 Lesion of Oral Cavity: Changing Trend
Introduction: Neck dissection is an important part in the management of head and neck malignancies especially in terms of control of nodal metastasis. The study is focused on evaluating the profile of lymph nodes in T3 N...
Excision Versus Fixation of the Radial Head: A Comparative Study of the Functional Outcomes of the Two Techniques
Introduction: The management of displaced and comminuted radial head fractures has been a matter of debate amongst surgeons for many years. Radial head excision formed the mainstay of surgical management of these injurie...