Butanol soluble fractions of Cissus cornifolia methanolic leaf extract and behavioural effects in mice
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 4
Abstract
Cissus cornifolia Baker - Planch (Family: Vitaceae) is used for various central nervous system disorders. The present study reported the sedative and central nervous depressant effects of fractions (butanol soluble portion and its flavonoid rich fraction) obtained from methanolic leaf extract of Cissus cornifolia using diazepam induced sleep, head-dip and motor coordination tests in mice at doses between 5 to 600 mg/kg body weight. The flavonoid rich column fraction 3 (CF3) significantly (p <0.05) prolonged the duration of sleep in mice at the dose of 10 and 20 mg/kg. Similarly, the butanol soluble portion significantly (p <0.001) prolonged the duration of diazepam induced sleep at 150, 300 and 600 mg/kg in a dose dependent manner. It also significantly (p <0.05) decreased the onset of sleep at the dose of 150 and 600 mg/kg. A dose dependent and significant (p <0.001) decrease in the mean number of head-dips was produced by the butanol soluble portion at all the doses tested. The butanol soluble portion at all the doses tested significantly (p <0.005) prolonged the time to complete the beam walk, however the extract did not produce a significant increase in number of foot slips. The results demonstrated that the butanol soluble fractions obtained from methanolic leaf extract of Cissus cornifolia posses sedative and central nervous system depressant activity, thus supporting its ethno medicinal use as a sedative in the management of central nervous system disorders.
Authors and Affiliations
Abdullahi Hamza Yaro, Musa Aliyu Muhammad, Abdullahi Balarabe Nazifi, Mohammed Garba Magaji
Keywords
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