C-reactive protein as a diagnostic and prognostic factor in inflammatory bowel diseases
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2016, Vol 70, Issue
Abstract
Aim: The study aimed to evaluate high-sensitivity CRP (hsCRP) as a diagnostic and predictive marker in patients with inflammatory bowel disease (IBD). Material/Methods: Medical history of 106 patients with IBD revealed hsCRP concentrations at diagnosis and during the follow-up period.Results: The study showed that the majority of investigated patients had elevated hsCRP concentrations at diagnosis, although the mean concentration was much higher in the group of patients with Crohn’s disease (CD) than the group with ulcerative colitis (UC) (P<0.001). The overall decrease in mean hsCRP concentration observed during the follow-up period was larger in the group of CD patients. The analysis showed a correlation between hsCRP concentrations at diagnosis and risk of surgery in the group of CD patients (r=0.408, P=0.002), but not in the group of UC patients. In a logistic regression analysis, surgery in CD patients was associated with age (OR: 0.89, 95% CI: 0.8–1.0, P=0.05) and hsCRP concentration (OR: 1.02, 95% CI: 1.0–1.04, P=0.03) at diagnosis.Discussion: HsCRP might be a useful diagnostic marker in differentiating active IBD from other diseases. Particularly important however seems to be the predictive value of hsCRP at diagnosis in prognosing the clinical outcome of the disease in CD patients.
Authors and Affiliations
Dorota Mańkowska-Wierzbicka, Jacek Karczewski, Barbara Poniedziałek, Małgorzata Grzymisławska, Rafał Staszewski, Aleksandra Królczyk, Agnieszka Dobrowolska, Marian Grzymisławski
Keywords
Related Articles
- EP ID EP220876
- DOI -
- Views 156
- Downloads 0
Wpływ diety suplementowanej tyroksyną na wybrane wykładniki równowagi redox, morfologię wątroby i profil lipidowy szczurów poddanych działaniu doksorubicyny
Wprowadzenie: Cytotoksyczność doksorubicyny (DOX) – leku przeciwnowotworowego, jest w głównej mierze wynikiem generowania reaktywnych form tlenu (RFT). Niektóre z enzymów katalizujących tę reakcję, a także enzymów obrony...
Wartość prognostyczna ekspresji HER3, PTEN i p-HER2 u chorych na HER2-dodatniego raka piersi
A novel way to induce coronary hyperaemia
Coronary angiography and measurement of fractional flow reserve (FFR) are used for anatomical and functional assessment of coronary stenoses. The achievement of maximal coronary hyperaemia is crucial for an accurate calc...
Rola metody PCR w diagnostyce i badaniach naukowych Helicobacter pylori – nowe możliwości poznawcze formy kokoidalnej i spiralnej bakterii
Subclinical carotid atherosclerosis and cardiovascular risk factors in HIV-infected patients
Background: HIV infected patients, especially those treated with antiretroviral (ARV) drugs, show an increased risk and incidence of cardiovascular disease. Objectives: The aim of this study was to evaluate the progressi...