C-reactive Protein as a Diagnostic Marker of Bacterial Infection in Febrile Children
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 3
Abstract
ABSTRACT Introduction: Evaluation of febrile infants and children without focus possess a great clinical concern. Although several biochemical indices indicate diagnosis towards bacterial agents, combining low cost and easily performed haematological parameters could reasonably predict the presence of Bacterial Infection (BI). Aim: To assess the value of C-reactive Protein (CRP) alone and in conjunction with total White Blood Cell (WBC) count and Absolute Neutrophil Count (ANC) in predicting bacterial infection in febrile children. Materials and Methods: A prospective study was conducted in the Department of Paediatrics of a tertiary care hospital among children aged 1 month to 14 years admitted with fever for >24 hours. Data were collected from 97 consecutive children in whom CRP and total blood count was advised at admission. These data were analysed to predict the presence of BI by investigating the diagnostic performance of CRP, WBC and ANC using standard statistical software Stata version 13.1. Results: BI was diagnosed in 41 children. Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), Diagnostic Accuracy (DA) of CRP for BI among the febrile infants were 83%, 75.0%, 71%, 86% and 78% respectively. The sensitivity and specificity were 61% and 98% when all the three parameters CRP, WBC and ANC were positive and were 95% and 45% when any of these parameters was positive. Conclusion: A definitive cut-off value of 1.2 mg/L for CRP is a reasonably good predictor of BI among febrile children. However, addition of other laboratory parameters (total leukocyte count and ANC may enhance clinician’s ability to discriminate bacterial from non BIs.
Authors and Affiliations
Bandya Sahoo, Bhaskar Thakur, Mukesh Kumar Jain, Reshmi Mishra
Keywords
Related Articles
- EP ID EP514179
- DOI 10.7860/JCDR/2018/34233.11259
- Views 54
- Downloads 0
A Study of the Growth of Human Foetal Lung in Relation with the Gestational Age
ABSTRACT Introduction: Lung is one of the organs of interest for researchers since a long time. Though detailed study about adult lung is there in the literature but study of lungs at different stages in the fetal period...
Ex vivo Evaluation of the Erosive Effect of Acid Tea Widely Consumed in Brazil
ABSTRACT Introduction: Dental erosion is defined as the pathological, irreversible, chronic, and localised loss of dental enamel by prolonged acid action and often without bacterial involvement. Aim: To evaluate ex vivo,...
A Study to Compare Transurethral Resection of the Prostate and Inguinal Hernioplasty as Combined and Separate Procedures
ABSTRACT Introduction: Chance of recurring hernia depends greatly on type of surgical procedure and hernia. Practising Transurethral Resection of Prostate (TURP), hernioplasty as combined procedure is not infrequent alth...
Evaluation of Expression of HER2/neu in Intestinal and Diffuse Type Gastric Carcinomas by Immunohistochemistry
ABSTRACT Introduction: The management of gastric cancer in advanced stages, which is the second most leading cause of cancer mortality in the world, has evolved very little. Surgical resection remains the mainstay of tre...
Incidence and Outcomes of Early Stent Thrombosis in Patients Receiving Drug-eluting Stents: A Retrospective Study from a Tertiary Care Centre in India
ABSTRACT Introduction: Early stent thrombosis is a relatively rare but deleterious complication of Percutaneous Coronary Intervention (PCI). Data on early stent thrombosis from an Indian setting are rare and indistinct....