C-reactive Protein as a Diagnostic Marker of Bacterial Infection in Febrile Children
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 3
Abstract
ABSTRACT Introduction: Evaluation of febrile infants and children without focus possess a great clinical concern. Although several biochemical indices indicate diagnosis towards bacterial agents, combining low cost and easily performed haematological parameters could reasonably predict the presence of Bacterial Infection (BI). Aim: To assess the value of C-reactive Protein (CRP) alone and in conjunction with total White Blood Cell (WBC) count and Absolute Neutrophil Count (ANC) in predicting bacterial infection in febrile children. Materials and Methods: A prospective study was conducted in the Department of Paediatrics of a tertiary care hospital among children aged 1 month to 14 years admitted with fever for >24 hours. Data were collected from 97 consecutive children in whom CRP and total blood count was advised at admission. These data were analysed to predict the presence of BI by investigating the diagnostic performance of CRP, WBC and ANC using standard statistical software Stata version 13.1. Results: BI was diagnosed in 41 children. Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), Diagnostic Accuracy (DA) of CRP for BI among the febrile infants were 83%, 75.0%, 71%, 86% and 78% respectively. The sensitivity and specificity were 61% and 98% when all the three parameters CRP, WBC and ANC were positive and were 95% and 45% when any of these parameters was positive. Conclusion: A definitive cut-off value of 1.2 mg/L for CRP is a reasonably good predictor of BI among febrile children. However, addition of other laboratory parameters (total leukocyte count and ANC may enhance clinician’s ability to discriminate bacterial from non BIs.
Authors and Affiliations
Bandya Sahoo, Bhaskar Thakur, Mukesh Kumar Jain, Reshmi Mishra
Keywords
Related Articles
- EP ID EP514179
- DOI 10.7860/JCDR/2018/34233.11259
- Views 65
- Downloads 0
Comparative Study of Etomidate and Midazolam with Fentanyl as Inducing Agents in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery
ABSTRACT Introduction: Off-pump Coronary Artery Bypass Graft (CABG) surgery has promising out come with minimal morbidity and mortality. Conduction of anaesthesia is still a challenge in Coronary Artery Disease (CAD) pat...
Effect of Recumbent Body Positions on Dynamic Lung Function Parameters in Healthy Young Subjects
Introduction: The change in body position can alter pulmonary functions parameters, therefore it is important to understand the physiological basis of these alteration. Ideally, spirometry is done in sitting position unt...
Relationship between Maternal General and Specific-Pregnancy Stress, Anxiety, and Depression Symptoms and Pregnancy Outcome
Introduction: Despite scientific advances in the field of physical problems during pregnancy, the effect of mental problems on the health of pregnant women is still an important issue that needs further research. Aim: To...
Chondroid Lipoma in Left Thigh –A Rare Case Report
Chondroid lipoma is a rare variant of lipoma and often confused with chondroid tumours such as soft tissue chondroma, extraskeletal chondrosarcoma and myxoid chondrosarcoma. It consists of two components – adipose tissue...
Comment on “Serological Evidence of Scrub Typhus among Cases of PUO in the Kashmir Valley- A Hospital Based Study”
Letter to Editor