C-Reactive Protein to Albumin Ratio: A Reliable Marker in Colorectal Cancer
Journal Title: Turkish Journal of Colorectal Disease - Year 2021, Vol 31, Issue 1
Abstract
Aim: Postoperative complications after colorectal cancer surgery result in increased treatment costs, prolonged hospital stays and poor prognosis and reduce quality of life of the patients. Here, we aim to contribute to the literature in terms of being a reliable marker of postoperative C-reactive protein (CRP) to albumin ratio (CAR) after colorectal cancer surgery. Method: A total of 213 patients undergoing colorectal cancer surgery between 2013 and 2018 were analyzed in this study. Risk factors for the development of postoperative complications were analyzed using univariate and multiple logistic regression models. A receiver operating characteristic (ROC) curve analysis was used to analyze the association with the CRP and CAR variables, with the aim being to differentiate postoperative complications. Results: Postoperative complications occurred in 87 (40.8%) patients. Based on the Clavien-Dindo classification, 25 (18.7%) patients developed major complications. Perioperative blood transfusion [odds ratio (OR)=1.3; 95% confidence interval (CI)=1.08-1.55] and postoperative CAR (OR=1.2; 95% CI=1.05-1.35) were independent risk factors for postoperative complications (p=0.005 for each). The cut-off value for CAR was 4.3 (sensitivity: 51.72; specificity: 71.43; and area under the curve: 0.642), meaning that CAR was found to be statistically significantly effective in differentiating postoperative complications (p<0.001). The (median) length of hospital stay was statistically significantly longer in the high CAR (>4.3) group (p=0.001), while the laparoscopic surgery rate was statistically significantly lower in the high CAR group (p=0.039). Conclusion: CAR is a novel, reliable and independent marker. Moreover the ratio is useful for clinicians and provides the determination of early postoperative complications after colorectal cancer surgery.
Authors and Affiliations
Özlem Zeliha Sert, Hilmi Bozkurt, Tolga Ölmez, Emre Aray, Orhan Uzun, Selçuk Gülmez, Aziz Serkan Zenger, Erdal Polat, Mustafa Duman
Comparison of Laparoscopic Embedding Technique and Other Techniques for Appendiceal Stump Closure
Aim: Acute appendicitis is the most common surgical emergency worldwide. Laparoscopic appendectomyis widely used in acute appendicitis. In our study, we aimed to investigate the efficacy and safety of laparoscopic embedd...
Penetrating Sharp Object Injury in the Gluteal Region and Small Bowel Perforation Due to Pelvic Penetration: A Case Report
Penetrating sharp object injuries in the gluteal region are common. However, it is very rare that these injuries lead to perforation of the small bowel by pelvic penetration, which is generally overlooked. As penetration...
Effects of the COVID-19 Pandemic on General Surgery Training in Turkey
Aim: The Coronavirus disease-19 (COVID-19) pandemic has affected all countries in the world and has created a serious burden on the health systems of countries. Although health systems, which have not encountered such a...
Our Colonoscopic Screening Results According to Risk Groups in Colorectal Cancers (Pilot Study)
Aim: Most of the colorectal cancers develop on a pre-existing polyp background. With the widespread use of screening tests, mortality of colorectal cancers has been shown to decrease. Our aim in this pilot study is to sc...
Effect of Body Mass Index and Fat Mass Measured Using a Tanita Body-fat Analyser on Caecal Intubation Time: A Prospective Clinical Study
Aim: Factors such as the endoscopist’s experience, bowel preparation and past abdominal surgery all affect caecal intubation time (CIT) in colonoscopy procedures. The present study investigated the effects of body mass i...