Can adding Ephedrine to Admixture of Propofol & Lidocaine Overcome Propofol Associated Hemodynamic Changes and Injection Pain?
Journal Title: International Journal of Anesthesiology & Research (IJAR) - Year 2016, Vol 4, Issue 3
Abstract
Purpose: There are numerous studies researching ways to alleviate propofol injection pain. In this study, we evaluated and compared the use of propofol-lidocaine admixture vs propofol-lidocaine combined with ephedrine, on vascular pain and hemodynamic changes associated propofol. Methods: This double-blinded, prospective, randomised study was performed on 100 patients with ASA I-II who were divided into two group. The first received admixture consisting of 20 mg of lidocaine and propofol 1% 20 ml (Group L), and the other received admixture consisting of 20 mcg ephedrine, 20 mg lidocaine and propofol 1% 20 ml (Group LE). Baseline and after induction heart rate, mean arterial pressure and rate pressure product (RPP) were recorded per minute. Vascular pain were evaluated with verbal rating scale. Results: Data of 40 patients in group L and 39 patients in Group LE were evaluated in the study. The incidence of pain in group L was 90%, it was 38.4% for Group LE. Mild pain was observed significantly more in Group L when compared to Group LE (p<0.05). Average blood pressure and RPP immediately after induction and 1 min after intubation were significantly higher in group LE compared to group L (p<0.05). Heart rate was higher in Group LE immediately after induction and at initially 4 minutes after intubation. Conclusion: Our study has demonstrated significant decrease in rate of vascular pain and increased hemodynamic stability in patients receiving 20 mg ephedrine added to 20 ml % 1 propofol and 20 mg lidocaine admixture when compared to those who only received the lidocaine-propofol admixture.
Authors and Affiliations
Dr. Serkan Tulgar
Keywords
Related Articles
- EP ID EP202293
- DOI 10.19070/2332-2780-1600049
- Views 84
- Downloads 0
Retrospective Assessment Of Postoperative Pain Control With Intravenous Or Epidural Patient-Controlled Analgesia After Orthopedic, General And Plastic Surgery
Aim: Patient-controlled analgesia methods are more effective than conventional analgesia methods for the management of postoperative pain. Patient-controlled analgesia is often preferred as it has less sedative effect, m...
Coconut Oil as an Adjuvant to Magnesium Sulphate Therapy in Acute Aluminum Phosphide Consumption
Objective: Aluminium phosphide (ALP) poisoning is becoming a serious health care problem in India. It has high mortality rate in spite of aggressive intensive management. Aim: This study is designed to assess the effec...
Place of the Post-Anesthesia Care Unit in Patient Care after Anesthesia
Aim: The aim of this study is to emphasize that the post-anesthesia care unit provides good quality service and is an important place for treatment of patients at high risk of postoperative complications. Material And M...
Serotonin Syndrome Following Methylene Blue Administration for Vasoplegic Syndrome in Heart and Lung Transplantation – A Case Series
Serotonin syndrome is a potentially life threatening adverse drug reaction caused by excessive activation of postsynaptic serotonin receptors in the central nervous system (CNS). It is typically associated with the simul...
Management of Postoperative Bleeding after Minimally Invasive Mitral Valve Repair: A Case Report
Excessive postoperative bleeding after cardiac surgery is one of the major risk factors for increased morbidity and mortality. Effective and timely management is essential in averting the need for surgical re-exploration...