Can brain natriuretic peptide predict cardiovascular complications in severe preeclampsia? A case-control study
Journal Title: International Journal of Reproductive BioMedicine - Year 2019, Vol 17, Issue 4
Abstract
Background: Preeclampsia is one of the most common pregnancy complications, which is one of the major causes of fetal and maternal mortality. Objective: To compare the serum Brain Natriuretic Peptide (BNP) level in patients with severe preeclampsia and normal pregnancy and investigate associated cardiovascular complications. Materials and Methods: This case-control study was performed on 94 women with a singleton pregnancy (severe preeclampsia and normal pregnancy) at Imam Reza Hospital in Mashhad, Iran. The venous blood samples were collected to evaluate the serum BNP level. All patients were subjected to echocardiography performed by a single cardiologist. Results: The mean pro-BNP levels were 480.36 ± 754.52 and 67.46 ± 106.24 pg/dL in the severe preeclampsia and normal pregnancy patients, respectively (p < 0.001). However, adjusted BNP for maternal and gestational age was not different in the two groups (ANCOVA, p = 0.69). Furthermore, the two study groups showed no significant difference in terms of the cardiac parameters, including ejection fraction (EF), left ventricle end-diastolic and -systolic diameters (LVEDD and LVESD, respectively), tricuspid annular plane systolic excursion (TAPSE), and ratio of the early transmitral flow velocity to the early diastolic tissue velocity (E/Em). However, the serum BNP level showed a significant correlation with EF (r = -0.39, p = 0.008), TAPSE (r = -0.47, p = 0.001), and E/Em ratio (r = 0.48, p = 0.001) in patients with severe preeclampsia. Conclusion: It seems that BNP can be used as a predictor for some of the main cardiac functional indices (i.e., E/Em, EF, and TAPSE) in severe preeclampsia patients.
Authors and Affiliations
Nayereh Ghomian, Farveh Vakilian, Bahram Shahri, Vesam Rostaminejad, Majid Khadem- Rezaiyan
Keywords
Related Articles
- EP ID EP642624
- DOI -
- Views 109
- Downloads 0
Multiplex PCR based screening for micro/partial deletions in the AZF region of Y-chromosome in severe oligozoospermic and azoospermic infertile men in Iran
We interested in a very nice article by Motovali-Bashi at al entitled as “Multiplex PCR based screening for micro/partial deletions in the AZF region of Y-chromosome in severe oligozoospermic and azoospermic infertile me...
Hypertensive disorders of in-vitro fertilization pregnancies: A study from Kosovo
Background: Relationships between in-vitro fertilization (IVF), gestational hypertension, and pregnancy outcomes are demonstrated in a number of studies. However, it is still debated if IVF treatment or specific characte...
Protective effects of melatonin and ghrelin on spermatogenesis: A narrative review of the literature
Spermatocytogenesis starts from lumens of seminiferous cords and after migration to the basal membrane ends to the lumens again. We attempt to review the protective effects of melatonin and ghrelin on Spermatocytogenesis...
The efficacy of group counselling on perceived stress among infertile women undergoing in vitro fertilization treatment: An RCT
Background: One of the stressful and critical experiences that threat the individual, family, marital, and social stability is infertility. Objective: To identify the effects of midwifery-led counselling programs on the...
Psychometric properties of the satisfaction with life scale (SWLS) in Iranian infertile women
Background: Infertility is a global public health issue and may adversely affect life satisfaction. One of the most widely instruments used to assess life satisfaction is the Satisfaction with Life Scale (SWLS). Objecti...