Can daily repeated doses of orally administered glucose induce tolerance when given for neonatal pain relief?
Journal Title: Acta Paediatrica - Year 2004, Vol 93, Issue 2
Abstract
AIM: Orally administered sweet solutions have a pain-relieving effect during painful procedures in newborn infants. The underlying mechanism is not fully understood, but, from the results of animal research, an opioid-like mechanism is often suggested. The aim of this study was to determine whether repeated doses of orally administered glucose would cause tolerance to glucose. METHODS: Fifty-seven healthy, full-term infants were recruited on the day of birth to receive three daily doses of either 1 ml 30% glucose or sterile water for 3-5 d, after which routine blood samples were collected by heel-lance. All infants received 1 ml 30% glucose before the heel-lance was carried out. Crying time, Premature Infant Pain Profile scores and changes in heart rate were used as pain measures. RESULTS: No differences were found between the groups, either in demographic data or in the outcome variables. CONCLUSION: No tolerance was observed under the conditions prevailing in this study. However, we cannot rule out an endogenous opioid mechanism. What is clinically important is that repeated doses of glucose do not decrease the pain-relieving effect.
Authors and Affiliations
Mats Eriksson, O Finnström
Keywords
Related Articles
- EP ID EP82285
- DOI -
- Views 139
- Downloads 0
Can severity-of-illness indices for neonatal intensive care predict outcome at 4 years of age?
AIM: To test four neonatal severity-of-illness indices (CRIB, NTISS, SNAP, SNAP-PE) for their ability to predict short- and long-term outcome in very low-birthweight infants receiving neonatal intensive care. METHODS: Da...
Paediatric metabolic syndrome and associated anthropometric indices: the CASPIAN Study.
AIM: To determine the prevalence of paediatric metabolic syndrome (MetS) and its best predictive anthropometric index. METHODS: This national study was conducted among 4811 students (2248 boys and 2563 girls) aged 6-18 y...
Prediction of respiratory distress syndrome by the microbubble stability teston gastric aspirates in newborns of less than 32 weeks' gestation.
AIM: There is a need for a rapid method to identify infants who will developrespiratory distress syndrome (RDS) soon after birth, to allow early treatment of affected infants withsurfactant. The microbubble stability tes...
Can daily repeated doses of orally administered glucose induce tolerance when given for neonatal pain relief?
AIM: Orally administered sweet solutions have a pain-relieving effect during painful procedures in newborn infants. The underlying mechanism is not fully understood, but, from the results of animal research, an opioid-li...