Can high normal TSH level predispose to hypercholesterolemia?
Journal Title: International Archives of Integrated Medicine - Year 2016, Vol 3, Issue 8
Abstract
Background: Thyroid hormone plays an important role in carbohydrate, protein, and lipid and electrolyte metabolism. Studies have demonstrated the association of hypothyroidism with dyslipidaemia. However the impact of high normal TSH on lipid profile is lacking. Also, thyroid hormone is known to influence glomerular filtration rate, and renal electrolyte handling. So, this study compared TSH levels in normal ranges with fasting lipid profile and electrolytes. Objectives: To measure and compare the levels of serum TSH, fasting lipid profile and electrolytes in euthyroid individuals with normal TSH and to correlate serum TSH with lipid profile and electrolytes across different age groups in both sexes. Materials and methods: After obtaining ethical clearance, 2 ml of fasting venous blood sample was drawn from 200 subjects (males=100, females=100) aged between 20-75years who consented to participate. Serum was used for estimation of TSH, lipid profile and electrolytes. TSH was measured by 4th generation Immunoassay in Cobas 6000 e601 autoanalyzer (Roche). The lipid profile and electrolytes were assayed in Cobas 6000 c501 autoanalyzer (Roche). Results: Serum TSH values showed significant positive correlation with total cholesterol (p=<0.001), triglycerides (p=<0.001) and LDL cholesterol (p=<0.001), but did not show any significant correlation with HDL cholesterol. Also serum TSH showed significant negative correlation with sodium (r=-0.185, p=0.048) and potassium (r=-0.205, p=0.028) levels. Conclusion: TSH and thyroid status can influence lipid and electrolyte metabolism. High normal TSH level may predispose to hypercholesterolemia and hypertriglyceridemia. High normal TSH patients can have lower serum electrolytes.
Authors and Affiliations
Pushkal SR, Vijetha Shenoy Belle, Krishnananda Prabhu
Keywords
Related Articles
- EP ID EP487815
- DOI -
- Views 135
- Downloads 0
Effect of partographic monitoring on outcomes for women in spontaneous labour at term
Background: Partogram is a graphic record of progress of labour and fetal condition during labour. The main parameter for recording progress of labour is the rate of cervical dilatation. Aim and objectives: To determine...
Role of Glycemic control and Lipid profile in management of Diabetic complications
Background: Diabetes mellitus is one of the most common endocrine disorders affecting about 6% of the world’s population. Diabetes mellitus is the leading cause of end stage renal disease (ESRD), a major cause of non-tra...
Study of association between expression of E-cadherin and Autocrine Motility Factor in different grades of Colorectal adenocarcinoma
Though incidence of Colorectal carcinoma is relatively less in consideration of world wide data, Indian scenario differs in higher incidence of Grade 3 carcinoma with signet ring cell component. We tried to find associat...
Dengue presenting as Acute Liver Failure – A case report
Background: Dengue is the most common arboviral illness in humans. It is transmitted by mosquitoes of the genus Aedes, which are widely distributed in subtropical and tropical countries. The dengue virus has four related...
Fine Needle Aspiration Cytology of Breast Carcinoma: A Comparative Study between Cytological and Histopathological Grading System with Lymph Node Status Assessment
Introduction: Breast carcinoma is the most common malignancy and the leading cause of death in women. Fine needle aspiration cytology (FNAC) plays a critical role in early diagnosis of any palpable breast lump. Aim and...