Can miliary tuberculosis be an indicator for tuberculous meningitis? Evaluation of the twenty-five adult cases with meningitis accompanied by miliary tuberculosis
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2016, Vol 6, Issue 2
Abstract
Objective: This study aimed to compare the characteristics of the tuberculous meningitis (TBM) patients with and without miliary tuberculosis (TB). Methods: Twenty-five patients with miliary TB of 160 patients with TBM were included in this retrospective study. Diagnosis of TBM was based on anamnesis, clinical and laboratory results, neuroradioogical signs and “Thwaites’ Diagnostic Index” while miliary TB was diagnosed by radiological imaging. Statistical analyses were performed using Chi-square test. Results:Of 25 patients with miliary TB, 14 were female and the median age was 35.3. Ages ranged between 20-35 and 17-78 years in male and female subjects, respectively. Most common symptoms at baseline were headache (84%), malaise-anorexia (68%) and nausea-vomiting (64%) while the most common findings were nuchal stiffness (84%) and fever (68%). The patients with miliary TB revealed longer symptom duration and higher rates of malaise-anorexia, night sweats, weight loss and higher protein levels in CSF than the others (p<0.05). Conclusion:Miliary TB could be an indicator for TBM in countries with high prevalence of TB. Female predominance, longer symptom duration and higher protein levels in CSF were remarkable in the patients with TBM accompanied by miliary TB.J Microbiol Infect Dis 2016;6(2): 74-79 Key words: Miliary tuberculosis, Mycobacterium tuberculosis, tuberculosis.
Authors and Affiliations
Sevtap Gursoy, H. Ahmed Kehribar , Kadriye Yasar, Semsi Karabela, Özlem A. Aydin, M. Emirhan İsik, E. Rahsan İnce, Mehmet Bakar, Filiz Pehlivanoglu , Gonul Sengoz
Keywords
Related Articles
- EP ID EP154192
- DOI 10.5799/ahinjs.02.2016.02.0220
- Views 101
- Downloads 0
Otogenic meningoencephalitis caused by Streptococcus pneumoniae
Meningitis/ meningoencephalitis due to Streptococcus pneumoniae are with severe course and high mortality rate. A case of severe meningoencephalitis by S. pneumoniae secondary to chronic bilateral otitis and mastoiditis...
Pathogenic Vibrio Strains Isolated from Human Stool and Water Samples from Western Kenya
Objective: Investigate the type of pathogenic Vibrio strains from water and stool samples collected from Migori, SonduMiriu, Nyando and Yala regions in Western Kenya. Methods: A total of 811 samples (596 wate...
Effect of temperature on storage of ethionamide during susceptibility testing
Objective: Ethionamide being thermolabile in nature, effect of temperature on the drug and its stability in liquid and solid media during susceptibility testing procedures was assessed to understand the inconsistency in...
Bombay’da bir üçüncü basamak hastanede Karbapenem dirençli Enterobacteriaceae sıklığı
Amaç: Karbapenem dirençli Enterobacteriaceae (CRE) enfeksiyonlarındaki artış halk sağlığı için önemli bir tehdit oluşturmaktadır çünkü bu bakterilerin enfeksiyonlarında kullanılabilecek sınırlı sayıda antibiyotik vardır...
Surveillance of Vancomycin-resistant Enterococci colonization with GeneXpert vanA/vanB test and culture method
Objectives:Early detection of vancomycin resistant enterococci (VRE) colonization in hospitalized patients plays an important role in controlling enterococcal infections. For this purpose, the detection of VRE from recta...