Can miRNA712_3p be a promising biomarker for early diagnosis of toxoplasmosis?
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2018, Vol 11, Issue 12
Abstract
Objective: To assess the role of miRNA712_3p as a specific biomarker in early detection of toxoplasmosis in plasma of mice acutely infected with Toxoplasma gondii. Methods: Real-time PCR was used to measure the level of miRNA712_3p in plasma of infected mice. Immune-competent and immune-suppressed mice were examined, three and five days post-infection. Results: Results revealed significant up-regulation of plasma miRNA712_3p in both immune- competent and immune-compromised groups in comparison to the control non-infected group. Additionally, an increase in the level of miRNA712_3p was noticed correspondently in the parasite density detected in liver impression smears. Conclusions: miRNA712_3p can be used as a novel biomarker for the detection of Toxoplasma gondii infection in both immune-competent and immune-compromised host.
Authors and Affiliations
Nermine Mogahed Fawzy Hussein Mogahed
Keywords
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- EP ID EP426436
- DOI 10.4103/1995-7645.248341
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