Can miRNA712_3p be a promising biomarker for early diagnosis of toxoplasmosis?

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Can miRNA712_3p be a promising biomarker for early diagnosis of toxoplasmosis?

Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2018, Vol 11, Issue 12

Abstract

Objective: To assess the role of miRNA712_3p as a specific biomarker in early detection of toxoplasmosis in plasma of mice acutely infected with Toxoplasma gondii. Methods: Real-time PCR was used to measure the level of miRNA712_3p in plasma of infected mice. Immune-competent and immune-suppressed mice were examined, three and five days post-infection. Results: Results revealed significant up-regulation of plasma miRNA712_3p in both immune- competent and immune-compromised groups in comparison to the control non-infected group. Additionally, an increase in the level of miRNA712_3p was noticed correspondently in the parasite density detected in liver impression smears. Conclusions: miRNA712_3p can be used as a novel biomarker for the detection of Toxoplasma gondii infection in both immune-competent and immune-compromised host.

Authors and Affiliations

Nermine Mogahed Fawzy Hussein Mogahed

Keywords

In vitro and in vivo investigation of natural compounds from seed extract of Mucuna pruriens lacking L-DOPA for the treatment of erectile dysfunction

Objective: To investigate the biological effects of the Mucuna pruriens (M. pruriens) seed extracts that lacked L-DOPA, which was formerly reported as the active ingredient, on erectile dysfunction (ED) both in vitro and...

EP ID EP426436
DOI 10.4103/1995-7645.248341
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