Can procalcitonin be a diagnostic marker for catheter-related blood stream infection in children?
Journal Title: Jornal de Pediatria - Year 2016, Vol 92, Issue 4
Abstract
Objective The potential role of procalcitonin (PCT) in the diagnosis of catheter-related bloodstream infection (CRBSIs) is still unclear and requires further research. The diagnostic value of serum PCT for the diagnosis of CRBSI in children is evaluated here. Method This study was conducted between October 2013 and November 2014, and included patients with suspected CRBSI from 1 month to 18 years of age who were febrile, with no focus of infection, and had a central venous catheter. Levels of PCT and other serum markers were measured, and their utility as CRBSI markers was assessed. Additionally, the clinical performance of a new, automated, rapid, and quantitative assay for the detection of PCT was tested. Results Among the 49 patients, 24 were diagnosed with CRBSI. The PCT-Kryptor and PCT-RTA values were significantly higher in proven CRBSI compared to those in unproven CRBSI (p=0.03 and p=0.03, respectively). There were no differences in white blood cell count and C-reactive protein (CRP) levels between proven CRBSI and unproven CRBSI. Among the 24 patients with CRBSI, CRP was significantly higher among those with Gram-negative bacterial infection than in those with Gram-positive bacterial infections. PCT-Kryptor was also significantly higher among patients with Gram-negative bacterial infection than in those with Gram-positive bacterial infections (p=0.01 and p=0.02, respectively). Conclusions The authors suggest that PCT could be a helpful rapid diagnostic marker in children with suspected CRBSIs.
Authors and Affiliations
Yasemin Ozsurekci
Keywords
Related Articles
- EP ID EP513756
- DOI 10.1016/j.jped.2015.11.004
- Views 76
- Downloads 0
Randomized clinical trial to change parental practices for drug use in a telehealth prevention program: a pilot study
Objectives Programs for parents have been found to have a direct positive impact on reducing the consumption of psychoactive substances by adolescents, as well as having an indirect impact on reducing risk factors and in...
Empiric therapy with vancomycin in the neonatal intensive care unit: let's “get smart” globally!
Coagulase-negative staphylococci (CoNS) remain the most common organisms causing late-onset bloodstream infections (BSIs) among preterm infants in the neonatal intensive care unit (NICU).1–4 Since the vast majority, if n...
Nutritional management and postoperative prognosis of newborns submitted to primary surgical repair of gastroschisis
Objective Gastroschisis is a defect of the abdominal wall, resulting in congenital evisceration and requiring neonatal intensive care, early surgical correction, and parenteral nutrition. This study evaluated newborns wi...
Musculoskeletal pain and musculoskeletal syndromes in adolescents are related to electronic devices
Objective To evaluate television and simultaneous electronic devices use in adolescents with musculoskeletal pain and musculoskeletal pain syndromes. Methods A cross-sectional study was performed in 299 healthy adolesce...
Bullying behavior, youth's disease and intervention: which suggestions from the data for research on bullying in the Brazilian context?
Since the influential work by Dan Olweus,1 bullying has emerged as a major problem of the society all over world and across societies. The international literature reports rates of children and adolescents involved in bu...