Can serum biomarkers prognosticate out come of traumatic brain injury (TBI)?
Journal Title: Journal of Medical and Scientific Research - Year 2019, Vol 7, Issue 2
Abstract
Background: Studies regarding ability of serum markers to provide an early insight related to functional outcome of patients with traumatic brain injury (TBI) are limited. Objective: The objective of this study was to evaluate Glial Fibrillary Acidic Protein (GFAP) and S100B protein concentration in serum to predict outcome after traumatic brain injury. Methods and materials: Serum from 49 patients with traumatic brain injury (admission Glasgow Coma Scale ≤12) admitted in tertiary hospital for a period of one year was enrolled in study. All patients underwent an admission computed tomography (CT) scan as a part of their clinical evaluation. Serum levels of S100B & GFAP was measured using enzyme linked immunosorbent assay techniques. Demographic and outcome (Glasgow Outcome Scales) at 6th month of injury data were collected prospectively. Results: Serum levels of S100B and GFAP were elevated following TBI. Injury severity score showed significant positive Pearson’s correlation with S100B, but not with GFAP levels. GOS score at 6th month had significant negative correlation with S100B & GFAP levels. Median serum levels of GFAP & S100B were found to have increased in those patients who were dead compared to those alive, and likewise in patients with an unfavourable outcome compared to those with a favourable outcome. The Mann-Whitney test showed the statistical significance of the above results. Univariate logistic regression analysis revealed that both GFAP & S100B could help predict the outcome, along with GCS & CT scan brain. Multivariable analysis showed that S100B was the strongest in predicting outcome at 6 months of TBI (P<0.05). Conclusion: Serum levels of S100B and GFAP indicate the severity of brain damage and are correlated with neurological prognosis after TBI and may enhance prognostication when combined with clinical and radiological variables.
Authors and Affiliations
Raghavendra H, Varsha KS, Sobti S, Bhaskar S, Choudary A, Gupta LN
Keywords
Related Articles
- EP ID EP638826
- DOI 10.17727/JMSR.2019/7-9
- Views 92
- Downloads 0
Quality assurance of modern image guided 3D-conformal radiotherapy treatments
Purpose: To describe the Quality Assurance (QA) methods of modern Three-dimensional conformal radiotherapy (3DCRT) treatments such as image guided Intensity-modulated radiation therapy (IMRT), RapidArc, Stereotactic radi...
Antibiotic susceptibility pattern of Burkholderia cepacia complex from various clinical samples in a tertiary care center: A one year prospective study
Background: The Burkholderia cepacia complex (BCC) is a diverse group of human pathogens that cause life-threatening infections in patients with indwelling devices & those requiring intensive care. The aim of this study...
Primary melanocytic tumor of the cerebellopontine angle mimicking acoustic schwannoma: Case report
Intra-cranial melanomas are commonly metastatic, from primary melanoma elsewhere in the body. The primary occurrence of a melanoma in the brain parenchyma is rare. We report a case of 26-year aged woman who presented wit...
Suprasellar colloid cyst: An unusual location
Background: Colloid cysts are rare intracerebral lesions that are preferentially encountered within the third ventricle. There are only a few reports in which colloid cysts are described in other locations such as the fo...
Tubercular cold abscess of scapula: A rare presentation
Tuberculosis (TB) is a very common cause of morbidity and mortality as an infectious disease in endemic areas. Only 18 cases of scapular TB have been reported in the literature so far. In this case report, a patient was...