Can thyroid dysfunction in mothers influence neonatal thyroid profile?
Journal Title: Pediatric Review: International Journal of Pediatric Research - Year 2016, Vol 3, Issue 7
Abstract
Thyroid hormones play a critical role in normal CNS maturation. Fetus is entirely dependent on maternal thyroid hormone before the onset of endogenous thyroid hormone production. Maternal hypothyroidism alone during early gestation can lead to mild but significant cognitive impairment of the offspring. Infants of mothers with thyroid problem are more likely to have elevated TSH during newborn screening. Aim of the Study: The study was done to know whether maternal thyroid dysfunction can influence neonatal thyroid profile. Materials and Methods: This was a prospective cohort study in which 171 neonates who satisfied the inclusion criteria were serially enrolled during the study period. Of the 171 neonates enrolled, 70 neonates were born to mothers with thyroid dysfunction and 101 neonates were born to normal mothers. TSH estimation was done in all enrolled neonates at 72 hrs and result interpreted using AAP guidelines. Results: Out of 171 neonates, 155 babies (91%) had a TSH value of < 10 mIU/L ,14(8%) had TSH between 10 and 40 mIU/L and 2 babies (1%) had TSH > 40 mIU/L . All the neonates who had TSH > 40 mIU/L were born to mothers with thyroid dysfunction. Neonates who had TSH > 40mIU/L were all females where as there was a male predominance in the group who had TSH between 10 and 40 mIU/L. Conclusion: It may be concluded that maternal thyroid hormones play a crucial role in the thyroid function status of newborns and their early neurodevelopment.
Authors and Affiliations
Maya Menon, Sreejyothi. G, Raveendranath K
Keywords
Related Articles
- EP ID EP225875
- DOI 10.17511
- Views 144
- Downloads 0
Magnitude, clinical spectrum and etiology of hepatobiliary disorders in children- a tertiary care experience
Objectives: This study was undertaken to know about the magnitude, clinical spectrum and etiology of liver diseases in children in a tertiary care teaching hospital. Materials and Methods: This is a hospital based, retro...
Role of cord blood bilirubin and albumin levels as predictors of subsequent hyperbilirubinemia in newborns
Introduction: Neonatal hyperbilirubinemia is one of the most common problems in term and preterm babies. Development of hyperbilirubinemia in neonates is fretful for the parents and a concern for the pediatrician too. He...
A study on evaluation of waist height ratio as a screening tool for obesity
Introduction: Childhood obesity has become a single marker for children at risk for development of various noncommunicable diseases later in life. This study is conducted to estimate the prevalence of obesity and the ris...
Relationship between ABO blood group system and falciparum malaria in paediatric age group
Background: The associations of ABO blood group with different diseases were being reported from time to time. Recent works from different parts of the world have shown that O blood group is less prone and AB and B group...
Erosive esophagitis with transient respiratory distress in newborns: a case report
Isolated esophagitis is very rare in newborn infants at birth, although it may occur a few days or weeks later but is generally associated with gastritis or gastroesophageal reflux, infections or trauma. Respiratory dist...