Canakinumab in the Treatment of Erosive Hand Osteoarthritis: A Case Series
Journal Title: Journal of Case Reports and Studies - Year 2015, Vol 3, Issue 5
Abstract
Background: Erosive hand Osteoarthritis (EOA) is a common and debilitating form of hand OA for which there are no proven or efficacious therapies. Interleukin-1 beta (IL-1β) plays a prominent role in OA joint inflammation. Canakinumab is a selective IL-1β inhibitor. The author hypothesized that canakinumab would be effective in alleviating the symptoms and functional limitations of EOA. Methods: This prospective case series enrolled 3 patients with EOA who were treated with canakinumab 160 mg subcutaneously once. They were followed over a 12 week period, with visits at week 4, week 8, and week 12. It was anticipated that the effect of canakinumab would wear off and pain/function would return to baseline at week 12. The primary outcome of the study was improvement in QuickDASH at week 8. Secondary outcomes included changes in Health Assessment-Disability Index, subject reported pain, grip strength, and shirt button time. Subjects also had swollen and tender joint counts recorded. Erythrocyte Sedimentation Rate and C-Reactive Protein were measured. Results: No clinical or statistically significant improvement in QuickDASH, the primary study outcome, was noted. A minor trend in improvement was noted in shirt button time, but this improvement was not statistically significant. All other outcomes did not demonstrate any clinically or statistically significant trends. Conclusion: No clinical improvements in the various functional and clinical parameters studied were noted. The lack of effect of canakinumab and the small size of the trial should not dissuade future research.
Authors and Affiliations
Carroll MB
Keywords
Related Articles
- EP ID EP583052
- DOI 10.15744/2348-9820.3.503
- Views 95
- Downloads 0
A Rare Case of Small Cell Neuroendocrine Carcinoma of the Nasal Cavity and Paranasal Sinuses
Introduction: Neuroendocrine neoplasms are defined as epithelial neoplasms with predominant neuroendocrine differentiation. They are most commonly found in the gastrointestinal tract and respiratory system. Nasal cavity...
A New Platform for Sharing Research and Teaching Experience
Case reports are considered to be brief reports describing an episode of clinical case or a small number of cases. They may describe new or uncommon diagnoses, unusual outcomes or prognosis, new or unusual imaging findin...
A Traumatic Context Can Hide a Sexual Rape
Aeric syndrome during a multiple trauma reflects the severity of this latter, which made mention to extra thoracic or intra thoracic lesion. This requires a good diagnostic and therapeutic strategy. We report the case of...
Primary Cutaneous Hodgkin Lymphoma: A Rare Disease Variant and Review of the Literature
A 49-year-old man presented with a 2-year history of an enlarging ulcerated plaque over the right forearm with an associated history of pruritus. Skin biopsy demonstrated an infiltrate of lymphocytes in the dermis and su...
Persisting Cough as the Single Presenting Symptom of an Intrathoracic Tumor in a Nine-Month-Old Child with Adenovirus Airway Infection
We report on a nine-month-old girl who presented with persisting cough, and diminished ventilation of the left hemithorax. Viral pneumonia was suspected after Adenovirus detection by PCR, but chest X-rays showed a persis...