Canakinumab in the Treatment of Erosive Hand Osteoarthritis: A Case Series
Journal Title: Journal of Case Reports and Studies - Year 2015, Vol 3, Issue 5
Abstract
Background: Erosive hand Osteoarthritis (EOA) is a common and debilitating form of hand OA for which there are no proven or efficacious therapies. Interleukin-1 beta (IL-1β) plays a prominent role in OA joint inflammation. Canakinumab is a selective IL-1β inhibitor. The author hypothesized that canakinumab would be effective in alleviating the symptoms and functional limitations of EOA. Methods: This prospective case series enrolled 3 patients with EOA who were treated with canakinumab 160 mg subcutaneously once. They were followed over a 12 week period, with visits at week 4, week 8, and week 12. It was anticipated that the effect of canakinumab would wear off and pain/function would return to baseline at week 12. The primary outcome of the study was improvement in QuickDASH at week 8. Secondary outcomes included changes in Health Assessment-Disability Index, subject reported pain, grip strength, and shirt button time. Subjects also had swollen and tender joint counts recorded. Erythrocyte Sedimentation Rate and C-Reactive Protein were measured. Results: No clinical or statistically significant improvement in QuickDASH, the primary study outcome, was noted. A minor trend in improvement was noted in shirt button time, but this improvement was not statistically significant. All other outcomes did not demonstrate any clinically or statistically significant trends. Conclusion: No clinical improvements in the various functional and clinical parameters studied were noted. The lack of effect of canakinumab and the small size of the trial should not dissuade future research.
Authors and Affiliations
Carroll MB
Keywords
Related Articles
- EP ID EP583052
- DOI 10.15744/2348-9820.3.503
- Views 101
- Downloads 0
ESBL-Producing E. Coli in a Patient on Automated Peritoneal Dialysis
Peritoneal Dialysis (PD) is one of the 3 well-established modalities of renal replacement therapy used in patients with renal failure. Despite its significant role as a successful method of renal replacement therapy, PD...
An Interesting Coexistence of a Classical-Nodular and an Adenoid-Ulcerous Basal Cell Carcinoma in the Same Anatomic Location
Basal cell carcinoma is the most frequent malignant tumor of the skin, and the most common carcinoma found in some countries. The main clinical subtypes of BCC are nodular, superficial, pigmented and morpheaform. The maj...
External Jugular Vein Aneurysm with Thrombus Presenting as Neck Mass: A Case Report (Rare Case)
External jugular vein aneurysm with thrombosis presenting as neck swelling is a rare clinical entity and rarely encountered in routine clinical practice in otorhinolaryngology. We present a case of a 52-year-old female w...
Accidental Hypothermia in the Upper Midwest: A Dual Case Report Comparison
Accidental hypothermia is a potentially life-threatening situation that involves a debilitated patient and is a result of environmental exposure. In rural and isolated areas, rapid transport of a patient for definitive c...
Resolution of Complete Atrioventricular Block in a Patient with Severe Hypothyroidism
Causes for syncope are multifaceted. Hormonal etiology, specifically hypothyroidism, is associated with cardiac arrhythmias [1]. Sinus bradycardia, low voltage, nonspecific T-wave changes and dissociative atrioventricula...