Canakinumab in the Treatment of Erosive Hand Osteoarthritis: A Case Series
Journal Title: Journal of Case Reports and Studies - Year 2015, Vol 3, Issue 5
Abstract
Background: Erosive hand Osteoarthritis (EOA) is a common and debilitating form of hand OA for which there are no proven or efficacious therapies. Interleukin-1 beta (IL-1β) plays a prominent role in OA joint inflammation. Canakinumab is a selective IL-1β inhibitor. The author hypothesized that canakinumab would be effective in alleviating the symptoms and functional limitations of EOA. Methods: This prospective case series enrolled 3 patients with EOA who were treated with canakinumab 160 mg subcutaneously once. They were followed over a 12 week period, with visits at week 4, week 8, and week 12. It was anticipated that the effect of canakinumab would wear off and pain/function would return to baseline at week 12. The primary outcome of the study was improvement in QuickDASH at week 8. Secondary outcomes included changes in Health Assessment-Disability Index, subject reported pain, grip strength, and shirt button time. Subjects also had swollen and tender joint counts recorded. Erythrocyte Sedimentation Rate and C-Reactive Protein were measured. Results: No clinical or statistically significant improvement in QuickDASH, the primary study outcome, was noted. A minor trend in improvement was noted in shirt button time, but this improvement was not statistically significant. All other outcomes did not demonstrate any clinically or statistically significant trends. Conclusion: No clinical improvements in the various functional and clinical parameters studied were noted. The lack of effect of canakinumab and the small size of the trial should not dissuade future research.
Authors and Affiliations
Carroll MB
Keywords
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- EP ID EP583052
- DOI 10.15744/2348-9820.3.503
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