CANCER STEM CELL GENE VARIANTS AS A MODIFIER IN URINARY BLADDER CANCER PATIENTS
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 3
Abstract
Aim: Cancer stem cell surface markers are potent candidates for various cancers. Therefore, we investigated role of three cancer stem cell markers viz. CD24, CD26 and CD28 in risk prediction and prognosis of bladder cancer (BC) in North India. Results: We analysed CD24, CD26 and CD28 gene polymorphisms in 240 BC patients and 270 controls to find out combinations of genetic variants and confounding risk factors contributing to BC risk. Significant high risk in variant genotype of CD24rs3838646CA/Del (p=0.001), dominant model (p=0.027) as well as in allelic model (p=0.002) and reduced risk was seen in CD26rs7608798T/C (p=0.006, OR=0.572) and the dominant model, TC+CC also revealed reduced risk (p=0.043, OR= 0.695). No association was found based on tumor stage/grade and smoking habit of BC patients as well as those treated with BCG immunotherapy with any of the candidate gene variant. On performing haplotype analysis, we found significant association in one out of four sets with p=0.014; OR=1.615. Gene combination between CD24rs3838646CA/Del and CD26rs7608798T/C showed marginal association with BC risk. Conclusion: Our result suggests that CSC marker gene polymorphism could be used as a marker for risk prediction to BC. However, this study needs to be further validated in other ethnicities.
Authors and Affiliations
Dr. Rama Devi Mittal
Keywords
Related Articles
- EP ID EP649018
- DOI -
- Views 162
- Downloads 0
CIPROFLOXACIN INDUCED FIXED DRUG ERUPTION: A CASE STUDY
Fixed drug eruption (FDE) is a distinctive type of cutaneous drug reaction that characteristically recurs in the same locations upon reexposure to the offending drug. FDEs are less common than exanthematous (morbilliform...
MICROBIAL QUALITY ASSESSMENT OF KUNUN ZAKI BEVERAGE SOLD IN PORT HARCOURT, RIVERS STATE, NIGERIA
The microbial quality assessment of kunun zaki beverage sold in Port Harcourt, Rivers State, Nigeria was evaluated. The pH of the samples ranged from 3.44-4.34, while the colony forming units per milliliter (cfu/ml) of k...
USE OF CAD/CAM TECHNOLOGY IN DENTAL IMPLANT
Despite the predictable longevity of implant prosthesis, there is an ongoing interest to continue to improve implant prosthodontic treatment and outcomes. One of the developments is the application of computer-aided desi...
ARUM CYRENIACUM: INVESTIGATION OF VOLATILES AND HEAVY METALS REMOVING CAPACITY
Arum cyreniacum is an endemic Libyan plant growing in Aljabal Al-Akhder region.Though Arum species have been used since antiquity in herbal medicine for a wide array of human disorders, information on the medicinally imp...
IDENTIFICATION OF CARBAPENAMASE PRODUCTION IN MULTI DRUG RESISTANT GRAM NEGATIVE BACTERIA BY PHENOTYPIC METHODS FROM A TERTIARY CARE HOSPITAL OF WESTERN U.P. INDIA
Objectives: To determine the occurrence of carbapenam resistance among MDR-GNB isolates by phenotypic methods. Introduction: Cabapenams posses the broadest spectrum of activity against gram positive and gram negative bac...