Candida Infection in Intensive Care Unit Patients at Tertiary Care Hospital
Journal Title: Healthline - Year 2015, Vol 6, Issue 1
Abstract
[b]Introduction:[/b]Candidiasis is an opportunistic infection, an important cause of morbidity and mortality among the critically illIntensive Care Unit (ICU)patients. [b]Objective :[/b] The main aim of this study is to examine the trend of Candida infection in Intensive Care Unit (ICU) patients and to compare it with co- morbidities. All the patients admitted to Intensive Care Unit (ICU)were included in this study. [b]Method :[/b] A clinical and laboratory study of critically ill patients admitted at adult ICU, Civil hospital, Ahmedabad from August-October 2014 was done. Laboratory findings of cultures including the infecting Candida species, resistance to antifungals and clinical profile along with associated risk factors were analyzed. Overall 45 patients with positive blood culture and 116 patients with positive urine culture were included in the study. [b]Results : [/b]Total 32 cases of candidiasis were identified over the study period which includes 4 cases of candidemia and 28 cases of candiduria. The most common co-morbidities were prolonged ICU stay [for more than 4 days (100%)], multiple antibiotics [more than two (100%)], urinary catheterization (100%), diabetes (25%), mechanical ventilator support (31.25%) and central venous catheterization (9.3%). C. kruseiwas the most common species identified in blood and C. tropicalis in urine. The rates of susceptibility to antifungal agents were found as Amphotericin B (100%), Voriconazole (97%), Fluconazole (81%), Itraconazole (75%) and Miconazole (47%).[b] Conclusions :[/b] Prevalence of candidiasis in ICU is significantly high than general wards (p<0.0001). Most patients had one or more co-morbidities at the time of the diagnosis of candidemia. Prolonged ICU stay, multiple antibiotics, prolonged indwelling devices and diabetes mellitus were the common underlying conditions documented prior to candidemia.
Authors and Affiliations
Nidhi Barot, Mahendra Vegad, Sumeeta Soni, Kamal Sharma, Komal Shah
Keywords
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