Candida species oral detection and infection in patients with diabetes mellitus: a meta-analysis
Journal Title: Iberoamerican Journal of Medicine - Year 2021, Vol 3, Issue 2
Abstract
Introduction: Diabetes mellitus is a chronic metabolic disorder that induces elevated plasma glucose levels. Diabetic patients are more susceptible to infections, especially fungal infections. There is a direct relationship between increased blood glucose levels and the number of Candida hyphae in the oral mucosa. This study aimed to evaluate oral candidiasis and the different Candida species found in patients with and without diabetes mellitus. Methods: A search for studies on oral candidiasis and diabetes mellitus was carried out in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS) and Google Scholar. For dichotomous outcomes, the estimates of effects of an intervention were expressed as odds ratios (OR) using the Mantel-Haenszel (M-H) method with 95% confidence intervals. Results: 25 studies were included in this meta-analysis. Diabetes Mellitus patients tripled the probability of being infected by Candida species (OR:3.16, p<0.001). Likewise, Candida species infections were more likely in patients with poor glycemic control (OR:2.94, p<0.001) and with dentures (OR:2.22, p<0.001). In contrast, neither gender nor diabetes mellitus type of diabetes conditioned fungal infections (p>0.05). The most prevalent Candida species in both diabetics and controls were C. albicans and C. tropicalis. Diabetics had significantly fewer C. non-albicans species oral infections than non-diabetics (p=0.04). Conclusions: Diabetics are more prone to oral candidiasis, especially C. albicans infections.
Authors and Affiliations
Alberto RodrÃguez-Archilla, Claudia Piedra-Rosales
Keywords
Related Articles
- EP ID EP693824
- DOI https://doi.org/10.5281/zenodo.4495286
- Views 91
- Downloads 0
Giant gastroschisis with complete gastric herniation: A case report and review of the literature
Introduction: We report a case of gastroschisis seen in our center, highlighting the rarity of this clinical entity. The author equally reviewed the existing literature covering the epidemiology, etiopathogenesis, manage...
Retinitis pigmentosa associated with systemic light chain amyloidosis (AL amyloidosis)
Retinitis pigmentosa (RP) or hereditary retinal dystrophy is a rare disease that can be isolated (non-syndromic RP) or associated with other systemic signs (syndromic RP). Kidney damage is exceptionally reported in patie...
Knowledge, attitude and pattern of antibiotic utilization among Libyan University students in Zawia
Introduction: The antimicrobial agents have saved human from several infectious disease. However, bacteria have capability to develop to become resistant to antibiotics and incorrect use of antibiotics is the main determ...
How to apply Simulation-Based Learning in Medical Education?
Simulation-Based Learning is considered the best alternative teaching and assessment tool that able to make the change in education, training, improving the quality and assessing the performance of the medical students....
Critical Care Nursing
Everyday routine jobs, as well as suddenly specific situations, as well as severe medical conditions of a nurse, can be considerably psychophysically exhausted. It is therefore important for nurses to find a model to dea...