Candidal meningitis in disseminated candidiasis by Candida tropicalis - A rare case report from India
Journal Title: Indian Journal of Neurosciences - Year 2018, Vol 4, Issue 4
Abstract
IntroductionCandida spp are the normal flora of human body and do not cause CNS disease unless there is some immune disturbance The prevalence of non albicans species differed significantly in various geographic areas Candida tropicalis is a species that is now recognized as an important pathogen of debilitated individualsCase ReportA 70 year old female complaining of altered sensorium since 7 days with neck stiffness The patient was also had white plaques in the oral cavity and pharynx MRI scan showed bilateral cerebral infarcts in pre and post central gyral regions and left thalamus Thick curvilinear leptomeningeal enhancement along the bilateral parietal regions Gram stain of centrifused CSF throat swab showed presence of gram positive yeast budding cells Growth was curdy white on Saborauds dextrose agar and was negative for germ tube test Blue colored colonies were obtained on Candida chrome agar and considered as Candida tropicalis HIV status was negative The patient was administered intravenous liposomal amphotericin B along with regular insulin levitiracetam lobazam pheytoin and potassium supplementation along with IV fluids She was discharged from hospital with fluconazole maintenance doseConclusion Candida tropicalis is now recognized as an important pathogen of debilitated individuals Subclinical candidal colonization can make the individual more prone to develop systemic infection and disease Candida tropicalis infects meningeal layers brain parenchyma and also involves vasculature of brain Even though Systemic infections with Candida tropicalis may occur as terminal complications timely evaluation accurate diagnosis administration of specific and supportive treatment gives good prognosisKeywordsCandida tropicalis Disseminated Meningoencephalitis Amphotericin B
Authors and Affiliations
Naga Sri Latha Bathala, Anjaneyulu Kammineni
Keywords
Related Articles
- EP ID EP490492
- DOI 10.18231/2455-8451.2018.0049
- Views 84
- Downloads 0
Can we predict recurrence in ocular motor palsies? Clinico-investigational Study of 34 patient
Introduction: Ocular motor nerve palsies are common and disabling. Nearly 25% cases remain undiagnosed. Study of factors which predict recurrence and increase diagnostic yield, is important for prognostic and therapeutic...
Microsatellite instability and copy number variation in mitochondrial Displacement loop region in Juvenile myoclonic epilepsy
Introduction: Microsatellites undergo mutations at a very high rate ranging from 10-6 to 10-2 per generation, called as Microsatallite Instability (MSI). Such mutations are commonly caused by the loss of DNA mismatch rep...
Focal cortical dysplasia: a case report and review
Focal cortical dysplasia (FCDs) are increasingly diagnosed as a cause of symptomatic focal epilepsy in pediatric patients.A 7-year-old boy presented with intractable partial epilepsy since 3 years.Electroencephalography...
Brachial plexus injury presenting as focal myoclonus
Myoclonus is characterised by quick involuntary muscle jerks It can be focal or generalized It arises most commonly from the sensorimotor cortex brainstem or the spinal cord Rarely focal lesions of the peripheral nerves...
Cannabis induced psychosis in patient with traumatic brain injury
The association between TBI (traumatic brain injury) and psychosis remains a subject of debate and controversy. Differentiating patients with psychosis attributable to TBI and from patients with primary psychosis is diff...