Carbamazepine induced Stevens Johnson Syndrome in a patient of Migraine- An Observational Study
Journal Title: IJAR-Indian Journal of Applied Research - Year 2017, Vol 7, Issue 5
Abstract
Stevens-Johnson syndrome (SJS) is a rare but serious idiosyncratic drug reaction characterized by diffuse muco-epidermoid injury and high mortality. Keratinocytes in both skin and mucous membranes (including eyes, mouth and genitalia) are injured resulting in a diffuse maculopapular rash, blistering lesions and epithelial detachment with minimal force (Nikolsky's sign).An Indian woman of 46 years old with a past history of Migraine being treated with Carbamazepine (400mg Thrice Daily), admitted to a tertiary care hospital of Eastern India with pain in the mouth ,difficulty to eat food, swelling of the lips and maculopapular rash. Presumptive diagnosis of carbamazepine -induced Stevens-Johnson syndrome was made after excluding other causes. Carbamazepine was withdrawn and other supportive care (Intravenous Fluid, Injection Dexamethasone 8mg Twice Daily, Injection Paracetamol 100 mg Twice Daily, Triamcinolone oral paste local application Thrice Daily) was provided to the patient during her hospital stay. She recovered after 2 weeks. Thus, Carbamazepine can induce Stevens Johnson Syndrome and a strict vigilance of adverse drug reaction is required in patients being treated with Carbamazepine.
Authors and Affiliations
Manab Nandy, Nirmal Polle, Mustafa Asad, Sangeeta De, Piyalee Nandy, Abhijit Chaudhuri
Keywords
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