Cardiac vagal activity and daily clinical practice
Journal Title: Journal of Clinical and Translational Research - Year 2016, Vol 2, Issue 1
Abstract
During most of the day heart rate (HR) is dominated by cardiac vagal (parasympathetic) activity – a fact taught in physiology classes and duly repeated at the appropriate exams. Only later in medical practice does one become aware of the power of cardiac vagal innervation, mainly in extreme cases: when it leads to syncope by too much or to tachycardia by too little activity, as in severe diabetes. In the previous issue, Karemaker presents a coherent series of experiments to elucidate how the vagus nerve might control HR. The most important inputs for this control are bursts of baroreceptor afferent activity that are driven by the systolic rise in arterial pressure; emphasis was therefore put on burst-like vagal stimulation, as the expected outgoing reflex response of the vagus to the heart. The physician may ask, what is its significance for day-to-day medicine?
Authors and Affiliations
Luc Quintin, John M. Karemaker, Robin M. McAllen
Keywords
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