CARDIOPROTECTIVE EFFECT OF COMMELINA DIFFUSA LEAF EXTRACT ON DOXORUBICIN INDUCED CARDIOMYOPATHY IN RATS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 9
Abstract
Albino Wistar rats were pretreated with 200 and 400 mg/kg of ethanol extract of Commelina diffusa leaf for 20 days and simultaneous treatment with doxorubicin (cumulative dose of 15 mg/kg i.p. in six divided doses 2.5mg/kg body weight i.p of doxorubicin on 7th, 10th, 13th, 16th and 19th day of study). On the 20th day, parameters evaluated were, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), serum markers such as creatine kinase-MB (CK–MB), lactate dehydrogenase (LDH) and extent of lipid peroxidation viz. malondialdehyde (MDA) was estimated. Pretreatment with extract of Commelina diffusa at 200 and 400 mg/kg showed a significant decrease in the levels of triglycerides, cholesterol, LDL, VLDL, lipid peroxidation (MDA) and significant increase in the level of HDL when compared with the positive control p< 0.05. Extract treated groups also showed significant decrease in the levels of serum LDH and CK-MB, when compared with the positive control p< 0.05. The histopathological study of the extract treated rats further confirmed the cardio-protection of Commelina diffusa. In conclusion, ethanol extract of Commelina diffusa may confer cardio-protective function on doxorubicin induced cardiomyopathy in rats.
Authors and Affiliations
Dr. Sule O. J.
Keywords
Related Articles
- EP ID EP618645
- DOI -
- Views 166
- Downloads 0
THE EFFECT OF COUPLING EFFICIENCY ON THE YIELD AND PURITY OF OLIGONUCLEOTIDES SYNTHESIZED USING PHOSPHORAMIDITE METHOD.
Coupling efficiency is a way of measuring how efficiently the DNA synthesizer is adding new bases to the growing DNA chain. To measure coupling efficiency, dimethyl trityl (DMT) group is used, which is colorless when att...
THE PROBLEM OF HALAYEP AND SHALATIN TRIANGLE AND ITS EFFECT IN EGYPT AND SUDAN RELATIONS
The conflict between Egypt and Sudan about Halayep and shalatin triangle is a historical conflict about the region since 1958 after AL-Sudan independence about Egypt. But the conflict started again after an agreement bet...
EFFICIENCY OF SOME NUTRIENT SUPPLEMENTS ON BIODEGRADATION OF SPENT ENGINE OIL IN POLLUTED SOIL
The aim of this study was to evaluate the effect of some nutrient samples–chicken manure (CM), Nitrogen, phosphorus, potassium compound (NPK), Nitroben (Azotobacter/Azospirillum) (NT) and Azolla (AZ) as amendments for th...
COMPARATIVE PHARMACOGNOSTICAL AND UHPLC-QTOF MS ANALYSIS OF TWO SPECIES OF LILIUM
Two species of Lilium, Lilium lancifolium Thunb. and Lilium polyphyllum D. Don both belonging to family Liliaceae, are used extensively in Traditional Chinese Medicine (TCM) and Ayurveda, respectively. In the current stu...
SPECTROPHOTOMETRIC ANALYSIS OF DISSOLVED PHOSPHATES IN WATER: CASE STUDY OF RIVERS IN SAGAMU TOWNSHIP
A reproducible and accurate colorimetric method of analysis for the determination of organic phosphates in water was reported. The dissolved organic phosphate (D.O.P.) concentration in the river water was obtained as the...